Abstract
Some 15-20% of multiple adenomatous polyposis have no genetic explanation and 20-30% of colorectal cancer (CRC) cases are thought to be due to inherited multifactorial causes. Accumulation of deleterious effects of low-frequency dominant and independently acting variants may be a partial explanation for such patients. The aim of this study was to type a selection of rare and low-frequency variants (
Original language | English |
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Pages (from-to) | 709-16 |
Number of pages | 8 |
Journal | Journal of Human Genetics |
Volume | 57 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2012 |