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Role of the alternative sigma factors σE and σS in survival of Salmonella enterica serovar Typhimurium during starvation, refrigeration and osmotic shock

Research output: Contribution to journalArticle

  • A McMeechan
  • M Roberts
  • TA Cogan
  • F Jørgensen
  • A Stevenson
  • C Lewis
  • G Rowley
  • TJ Humphrey
Original languageEnglish
Pages (from-to)263 - 269
Number of pages7
Volume153 (1)
DatePublished - Jan 2007


The ability of Salmonella enterica serovar Typhimurium to survive environmental stress requires specific, coordinated, responses, which induce resistance to the stress condition. This study investigated the relative contribution of {sigma}E and {sigma}S, the sigma factors regulating extracytoplasmic and general stress response functions, respectively, to survival at low temperature and also in media of differing osmotic strength, conditions relevant to food preservation. To determine if low-temperature storage is a signal for {sigma}E- and {sigma}S-mediated survival, the ability of S. Typhimurium rpoE, rpoS and rpoE/rpoS mutants to survive in a saline starvation-survival model at a refrigeration temperature (4.5 °C) was examined. Under these conditions, the rpoE mutant was significantly (P

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Publisher: Society for General Microbiology

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