Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes

P F Chinnery, H R Elliott, S Patel, C Lambert, S M Keers, S E Durham, M I McCarthy, G A Hitman, A T Hattersley, M Walker

Research output: Contribution to journalArticle (Academic Journal)peer-review

58 Citations (Scopus)

Abstract

Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.
Original languageEnglish
Pages (from-to)1650-1
Number of pages2
JournalLancet
Volume366
Issue number9497
DOIs
Publication statusPublished - 5 Nov 2005

Keywords

  • DNA, Mitochondrial
  • Diabetes Mellitus, Type 2
  • Humans
  • Meta-Analysis as Topic
  • Poly C

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