Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes

P F Chinnery; H R Elliott; S Patel; C Lambert; S M Keers; S E Durham; M I McCarthy; G A Hitman; A T Hattersley; M Walker

doi:10.1016/S0140-6736(05)67492-2

Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes

P F Chinnery
, H R Elliott
, S Patel
, C Lambert
, S M Keers
, S E Durham
, M I McCarthy
, G A Hitman
, A T Hattersley
, M Walker

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

68 Citations (Scopus)

Abstract

Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.

Original language	English
Pages (from-to)	1650-1
Number of pages	2
Journal	Lancet
Volume	366
Issue number	9497
DOIs	https://doi.org/10.1016/S0140-6736(05)67492-2
Publication status	Published - 5 Nov 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA, Mitochondrial
Diabetes Mellitus, Type 2
Humans
Meta-Analysis as Topic
Poly C

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title = "Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes",

abstract = "Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95\% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.",

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author = "Chinnery, \{P F\} and Elliott, \{H R\} and S Patel and C Lambert and Keers, \{S M\} and Durham, \{S E\} and McCarthy, \{M I\} and Hitman, \{G A\} and Hattersley, \{A T\} and M Walker",

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doi = "10.1016/S0140-6736(05)67492-2",

language = "English",

volume = "366",

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TY - JOUR

T1 - Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes

AU - Chinnery, P F

AU - Elliott, H R

AU - Patel, S

AU - Lambert, C

AU - Keers, S M

AU - Durham, S E

AU - McCarthy, M I

AU - Hitman, G A

AU - Hattersley, A T

AU - Walker, M

PY - 2005/11/5

Y1 - 2005/11/5

N2 - Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.

AB - Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.

KW - DNA, Mitochondrial

KW - Diabetes Mellitus, Type 2

KW - Humans

KW - Meta-Analysis as Topic

KW - Poly C

U2 - 10.1016/S0140-6736(05)67492-2

DO - 10.1016/S0140-6736(05)67492-2

M3 - Article (Academic Journal)

C2 - 16271646

SN - 0140-6736

VL - 366

SP - 1650

EP - 1651

JO - Lancet

JF - Lancet

IS - 9497

ER -

Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes

Abstract

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Keywords

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