Roles for learning in mammalian chemosensory responses

Philip Griffiths, Peter Brennan

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)
320 Downloads (Pure)

Abstract

A rich variety of chemosignals have been identified that influence mammalian behaviour, including peptides, proteins and volatiles. Many of these elicit innate effects acting either as pheromones within species or allelochemicals between species. However, even innate pheromonal responses in mammals are not as hard-wired as the original definition of the term would suggest. Many, if not most mammalian pheromonal responses are only elicited in certain behavioural or physiological contexts. Furthermore, certain pheromones are themselves rewarding and act as unconditioned stimuli to link non-pheromonal stimuli to the pheromonal response, via associative learning. The medial amygdala, has emerged as a potential site for this convergence by which learned chemosensory input is able to gain control over innately-driven output circuits. The medial amygdala is also an important site for associating social chemosensory information that enables recognition of conspecifics and heterospecifics by association of their complex chemosensory signatures both within and across olfactory chemosensory systems. Learning can also influence pheromonal responses more directly to adapt them to changing physiological and behavioural context. Neuromodulators such as noradrenaline and oxytocin can plasticise neural circuits to gate transmission of chemosensory information. More recent evidence points to a role for neurogenesis in this adaptation, both at the peripheral level of the sensory neurons and via the incorporation of new neurons into existing olfactory bulb circuits. The emerging picture is of integrated and flexible responses to chemosignals that adapt them to the environmental and physiological context in which they occur.
Original languageEnglish
Pages (from-to)91-102
Number of pages12
JournalHormones and Behavior
Volume68
Early online date6 Sep 2014
DOIs
Publication statusPublished - Feb 2015

Bibliographical note

27 August 2014

Keywords

  • Mammalian pheromones
  • Olfactory bulb
  • Amygdala
  • Signature mixture
  • Learning
  • Noradrenaline
  • Vomeronasal
  • Neurogenesis
  • Bruce effect
  • Darcin

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