Routes, destinations and delays: recent advances in AMPA receptor trafficking

JM Henley; EAB Barker; O Glebov

doi:10.1016/j.tins.2011.02.004

Routes, destinations and delays: recent advances in AMPA receptor trafficking

JM Henley, EAB Barker, O Glebov

Research output: Contribution to journal › Article (Academic Journal) › peer-review

138 Citations (Scopus)

Abstract

synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.

Translated title of the contribution	Routes, destinations and delays: recent advances in AMPA receptor trafficking
Original language	English
Pages (from-to)	258 - 268
Number of pages	11
Journal	Trends in Neurosciences
Volume	34 (5)
DOIs	https://doi.org/10.1016/j.tins.2011.02.004
Publication status	Published - May 2011

Bibliographical note

Other: Review

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10.1016/j.tins.2011.02.004

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MECHANISMS CONTROLLING THE NUMBER AND LOCATION OF SYNAPTIC AMPR'S
Henley, J. M. (Principal Investigator)
1/01/08 → 1/01/13
Project: Research

Cite this

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title = "Routes, destinations and delays: recent advances in AMPA receptor trafficking",

abstract = "synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.",

author = "JM Henley and EAB Barker and O Glebov",

note = "Other: Review",

year = "2011",

month = may,

doi = "10.1016/j.tins.2011.02.004",

language = "English",

volume = "34 (5)",

pages = "258 -- 268",

journal = "Trends in Neurosciences",

issn = "1878-108X",

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AU - Henley, JM

AU - Barker, EAB

AU - Glebov, O

N1 - Other: Review

PY - 2011/5

Y1 - 2011/5

N2 - synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.

AB - synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.

U2 - 10.1016/j.tins.2011.02.004

DO - 10.1016/j.tins.2011.02.004

M3 - Article (Academic Journal)

C2 - 21420743

SN - 1878-108X

VL - 34 (5)

SP - 258

EP - 268

JO - Trends in Neurosciences

JF - Trends in Neurosciences

ER -

Routes, destinations and delays: recent advances in AMPA receptor trafficking

Abstract

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MECHANISMS CONTROLLING THE NUMBER AND LOCATION OF SYNAPTIC AMPR'S

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