Routes, destinations and delays: recent advances in AMPA receptor trafficking

JM Henley, EAB Barker, O Glebov

Research output: Contribution to journalArticle (Academic Journal)

120 Citations (Scopus)

Abstract

synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.
Translated title of the contributionRoutes, destinations and delays: recent advances in AMPA receptor trafficking
Original languageEnglish
Pages (from-to)258 - 268
Number of pages11
JournalTrends in Neurosciences
Volume34 (5)
DOIs
Publication statusPublished - May 2011

Bibliographical note

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