Bibliographical noteFunding Information:
J.B.R. has served as an advisor to GlaxoSmithKline and Deerfield Capital. He has received investigator-initiated grant funding from Eli Lilly, GlaxoSmithKline and Biogen for projects unrelated to this paper. M.L. has received lecture fees from Amgen, Astellas, Lilly, Meda, Renapharma, UCB Pharma, and consulting fees from Amgen, Radius Health, UCB Pharma, Renapharma, and Consilient Health. The other authors declare no competing interests.
We thank Anna Westerlund and Ulrika Björklund at the University of Gothenburg for excellent technical assistance. Single cell data analysis was performed by Sanna Abra-hamsson from the Bioinformatics Core Facility at the Sahlgrenska Academy. We thank Jian Q Feng from the Department of Biomedical Sciences at the Texas A&M University for providing the Dmp1-cre mice. This study was supported by the Swedish Research Council, the Swedish Foundation of Strategic Research, the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement in Gothenburg, the IngaBritt and Arne Lundberg Foundation, the Torsten and Ragnar Söderberg’s Foundation, the Knut and Alice Wallenberg Foundation, the Novo Nordisk Foundation, and the Adlerbertska Research Foundation. The Richards research group is supported by the Canadian Institutes of Health Research (CIHR: 365825; 409511), the Lady Davis Institute of the Jewish General Hospital, the Canadian Foundation for Innovation, the NIH Foundation, Cancer Research UK, Genome Québec, the Public Health Agency of Canada and the Fonds de Recherche Québec Santé (FRQS). J.B.R. is supported by a FRQS Clinical Research Scholarship. Support from Calcul Québec and Compute Canada is acknowledged. TwinsUK is funded by the Welcome Trust, Medical Research Council, European Union, the National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. These funding agencies had no role in the design, implementation or interpretation of this study. T.L.’s group has been financially supported by the Academy of Finland: grants 3322098, 286284, 117787; Competitive State Research Financing of the Expert Responsibility area of Tampere (grant X51001); Tampere University Hospital Supporting Foundation and Finnish Society of Clinical Chemistry.
© 2021, The Author(s).