Ru-Catalysed C-H Silylation of Unprotected Gramines, Tryptamines and their Congeners

Paul Gates, Karthik Devaraj, Carina Sollert, C. Juds, Lukasz T. Pilarski

Research output: Contribution to journalArticle (Academic Journal)peer-review

35 Citations (Scopus)
306 Downloads (Pure)

Abstract

Selective Ru-catalysed C2-H silylation of heteroarenes is presented. The transformation works with or without directing group assistance and requires no protecting groups. Gramines and tryptamines may be converted efficiently whilst avoiding deleterious elimination side-reactions. Mechanistic studies reveal an unusual activation of the indole C4-H bond by an electron-rich metal.
Original languageEnglish
Pages (from-to)5868-5871
Number of pages4
JournalChemical Communications
Volume52
Issue number34
Early online date1 Apr 2016
DOIs
Publication statusPublished - 30 Apr 2016

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