Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion: A Meta-analysis of Individual-Participant Data

Mark C Simmonds; Jennifer V E Brown; Morag K Heirs; Julian P T Higgins; Richard J Mannion; Mark A Rodgers; Lesley A Stewart

doi:10.7326/0003-4819-158-12-201306180-00005

Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion: A Meta-analysis of Individual-Participant Data

Mark C Simmonds
, Jennifer V E Brown
, Morag K Heirs
, Julian P T Higgins
, Richard J Mannion
, Mark A Rodgers
, Lesley A Stewart

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

318 Citations (Scopus)

Abstract

Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned.

Original language	English
Pages (from-to)	877-89
Number of pages	13
Journal	Annals of Internal Medicine
Volume	158
Issue number	12
DOIs	https://doi.org/10.7326/0003-4819-158-12-201306180-00005
Publication status	Published - 18 Jun 2013

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@article{f99475123d074540b5c3d46dd540a1af,

title = "Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion: A Meta-analysis of Individual-Participant Data",

abstract = "Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned.",

author = "Simmonds, \{Mark C\} and Brown, \{Jennifer V E\} and Heirs, \{Morag K\} and Higgins, \{Julian P T\} and Mannion, \{Richard J\} and Rodgers, \{Mark A\} and Stewart, \{Lesley A\}",

year = "2013",

month = jun,

day = "18",

doi = "10.7326/0003-4819-158-12-201306180-00005",

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publisher = "American College of Physicians",

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T1 - Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion

T2 - A Meta-analysis of Individual-Participant Data

AU - Simmonds, Mark C

AU - Brown, Jennifer V E

AU - Heirs, Morag K

AU - Higgins, Julian P T

AU - Mannion, Richard J

AU - Rodgers, Mark A

AU - Stewart, Lesley A

PY - 2013/6/18

Y1 - 2013/6/18

N2 - Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned.

AB - Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned.

U2 - 10.7326/0003-4819-158-12-201306180-00005

DO - 10.7326/0003-4819-158-12-201306180-00005

M3 - Article (Academic Journal)

C2 - 23778905

SN - 1539-3704

VL - 158

SP - 877

EP - 889

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

IS - 12

ER -

Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion: A Meta-analysis of Individual-Participant Data

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