Salt-induced condensation in actin-DNA mixtures

O. V. Zribi*, H. Kyung, R. Golestanian, T. B. Liverpool, G. C L Wong

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

9 Citations (Scopus)


Multivalent ions can induce condensation of like-charged polyelectrolytes into compact states, a process that requires different ion valence for different polyelectrolyte species. We have examined the trivalent ion-induced condensation behavior in binary anionic polyelectrolyte mixtures consisting of DNA coils and F-actin rods, and observe a micro-phase separation between the two polyelectrolytes into coexisting finite-sized F-actin bundles and DNA toroids. Further, by increasing the DNA volume fraction in the mixture, condensed F-actin bundles can be completely destabilized, leading to only DNA condensation within the mixture. We examine a number of possible causes and propose a model based on polyelectrolyte competition for ions.

Original languageEnglish
Pages (from-to)541-547
Number of pages7
Issue number4
Publication statusPublished - May 2005


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