SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

Sheila F Lumley; David W Eyre; Anna L McNaughton; Alison Howarth; Sarah Hoosdally; Stephanie B Hatch; James Kavanagh; Kevin K Chau; Louise O Downs; Stuart Cox; Laura Dunn; Anita Justice; Susan Wareing; Kate Dingle; Justine Rudkin; Kathryn Auckland; Alexander Fyfe; Jai Bolton; Robert Paton; Alexander J Mentzer; Katie Jeffery; Monique I Andersson; Tim James; Tim E A Peto; Brian D Marsden; Gavin Screaton; Richard J Cornall; Paul Klenerman; Daniel Ebner; David I Stuart; Derrick W Crook; Nicole Stoesser; Stephen H Kennedy; Craig Thompson; Sunetra Gupta; Philippa C Matthews

doi:10.2807/1560-7917.ES.2020.25.41.2001721

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

Sheila F Lumley, David W Eyre, Anna L McNaughton, Alison Howarth, Sarah Hoosdally, Stephanie B Hatch, James Kavanagh, Kevin K Chau, Louise O Downs, Stuart Cox, Laura Dunn, Anita Justice, Susan Wareing, Kate Dingle, Justine Rudkin, Kathryn Auckland, Alexander Fyfe, Jai Bolton, Robert Paton, Alexander J MentzerKatie Jeffery, Monique I Andersson, Tim James, Tim E A Peto, Brian D Marsden, Gavin Screaton, Richard J Cornall, Paul Klenerman, Daniel Ebner, David I Stuart, Derrick W Crook, Nicole Stoesser, Stephen H Kennedy, Craig Thompson, Sunetra Gupta, Philippa C Matthews

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

Abstract

SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

Original language	English
Journal	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Volume	25
Issue number	42
DOIs	https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721
Publication status	Published - Oct 2020

Research Groups and Themes

Covid19

Keywords

Adolescent
Adult
Antibodies, Neutralizing/blood
Antibodies, Viral/blood
Betacoronavirus/immunology
COVID-19
Cohort Studies
Coronavirus Infections/blood
England/epidemiology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G/blood
Middle Aged
Pandemics
Pneumonia, Viral/blood
Population Surveillance
Pregnancy
Pregnancy Complications, Infectious/blood
Pregnancy Trimester, First/blood
Prenatal Diagnosis
Prevalence
SARS-CoV-2
Seroepidemiologic Studies
Single-Blind Method
Young Adult

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Lumley, S. F., Eyre, D. W., McNaughton, A. L., Howarth, A., Hoosdally, S., Hatch, S. B., Kavanagh, J., Chau, K. K., Downs, L. O., Cox, S., Dunn, L., Justice, A., Wareing, S., Dingle, K., Rudkin, J., Auckland, K., Fyfe, A., Bolton, J., Paton, R., ... Matthews, P. C. (2020). SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(42). https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721

@article{03222364fa634e83830fc63adb370c43,

title = "SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020",

abstract = "SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3\% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.",

keywords = "Adolescent, Adult, Antibodies, Neutralizing/blood, Antibodies, Viral/blood, Betacoronavirus/immunology, COVID-19, Cohort Studies, Coronavirus Infections/blood, England/epidemiology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G/blood, Middle Aged, Pandemics, Pneumonia, Viral/blood, Population Surveillance, Pregnancy, Pregnancy Complications, Infectious/blood, Pregnancy Trimester, First/blood, Prenatal Diagnosis, Prevalence, SARS-CoV-2, Seroepidemiologic Studies, Single-Blind Method, Young Adult",

author = "Lumley, \{Sheila F\} and Eyre, \{David W\} and McNaughton, \{Anna L\} and Alison Howarth and Sarah Hoosdally and Hatch, \{Stephanie B\} and James Kavanagh and Chau, \{Kevin K\} and Downs, \{Louise O\} and Stuart Cox and Laura Dunn and Anita Justice and Susan Wareing and Kate Dingle and Justine Rudkin and Kathryn Auckland and Alexander Fyfe and Jai Bolton and Robert Paton and Mentzer, \{Alexander J\} and Katie Jeffery and Andersson, \{Monique I\} and Tim James and Peto, \{Tim E A\} and Marsden, \{Brian D\} and Gavin Screaton and Cornall, \{Richard J\} and Paul Klenerman and Daniel Ebner and Stuart, \{David I\} and Crook, \{Derrick W\} and Nicole Stoesser and Kennedy, \{Stephen H\} and Craig Thompson and Sunetra Gupta and Matthews, \{Philippa C\}",

year = "2020",

month = oct,

doi = "10.2807/1560-7917.ES.2020.25.41.2001721",

language = "English",

volume = "25",

journal = "Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin",

issn = "1025-496X",

publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",

number = "42",

}

Lumley, SF, Eyre, DW, McNaughton, AL, Howarth, A, Hoosdally, S, Hatch, SB, Kavanagh, J, Chau, KK, Downs, LO, Cox, S, Dunn, L, Justice, A, Wareing, S, Dingle, K, Rudkin, J, Auckland, K, Fyfe, A, Bolton, J, Paton, R, Mentzer, AJ, Jeffery, K, Andersson, MI, James, T, Peto, TEA, Marsden, BD, Screaton, G, Cornall, RJ, Klenerman, P, Ebner, D, Stuart, DI, Crook, DW, Stoesser, N, Kennedy, SH, Thompson, C, Gupta, S & Matthews, PC 2020, 'SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020', Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, vol. 25, no. 42. https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. / Lumley, Sheila F; Eyre, David W; McNaughton, Anna L et al.
In: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, Vol. 25, No. 42, 10.2020.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

AU - Lumley, Sheila F

AU - Eyre, David W

AU - McNaughton, Anna L

AU - Howarth, Alison

AU - Hoosdally, Sarah

AU - Hatch, Stephanie B

AU - Kavanagh, James

AU - Chau, Kevin K

AU - Downs, Louise O

AU - Cox, Stuart

AU - Dunn, Laura

AU - Justice, Anita

AU - Wareing, Susan

AU - Dingle, Kate

AU - Rudkin, Justine

AU - Auckland, Kathryn

AU - Fyfe, Alexander

AU - Bolton, Jai

AU - Paton, Robert

AU - Mentzer, Alexander J

AU - Jeffery, Katie

AU - Andersson, Monique I

AU - James, Tim

AU - Peto, Tim E A

AU - Marsden, Brian D

AU - Screaton, Gavin

AU - Cornall, Richard J

AU - Klenerman, Paul

AU - Ebner, Daniel

AU - Stuart, David I

AU - Crook, Derrick W

AU - Stoesser, Nicole

AU - Kennedy, Stephen H

AU - Thompson, Craig

AU - Gupta, Sunetra

AU - Matthews, Philippa C

PY - 2020/10

Y1 - 2020/10

N2 - SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

AB - SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

KW - Adolescent

KW - Adult

KW - Antibodies, Neutralizing/blood

KW - Antibodies, Viral/blood

KW - Betacoronavirus/immunology

KW - COVID-19

KW - Cohort Studies

KW - Coronavirus Infections/blood

KW - England/epidemiology

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Immunoglobulin G/blood

KW - Middle Aged

KW - Pandemics

KW - Pneumonia, Viral/blood

KW - Population Surveillance

KW - Pregnancy

KW - Pregnancy Complications, Infectious/blood

KW - Pregnancy Trimester, First/blood

KW - Prenatal Diagnosis

KW - Prevalence

KW - SARS-CoV-2

KW - Seroepidemiologic Studies

KW - Single-Blind Method

KW - Young Adult

U2 - 10.2807/1560-7917.ES.2020.25.41.2001721

DO - 10.2807/1560-7917.ES.2020.25.41.2001721

M3 - Article (Academic Journal)

C2 - 33094717

SN - 1025-496X

VL - 25

JO - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

IS - 42

ER -

Lumley SF, Eyre DW, McNaughton AL, Howarth A, Hoosdally S, Hatch SB et al. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2020 Oct;25(42). doi: 10.2807/1560-7917.ES.2020.25.41.2001721

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

Abstract

Research Groups and Themes

Keywords

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