'Schizophrenia postdrome': a study of low-level psychotic experience after remission of first-episode schizophrenia

Kate Burley, Rachel Upthegrove, Max Birchwood, Paul Patterson, Amanda Skeate

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

BACKGROUND: Despite remission being the primary objective following the first episode of schizophrenia, clinically stabilized patients nevertheless relapse.

AIM: To assess the extent and fluctuation of low-level psychotic symptoms in patients who are in remission after first-episode schizophrenia and consider whether this is equivalent to symptomatology experienced by those at 'ultra high risk' (UHR) of developing first-episode psychosis.

METHODS: We examined the phenomenological characteristics of 11 patients who fulfilled international remission criteria using the Structured Interview for Prodromal Symptoms and compared this cohort with an UHR sample.

RESULTS: Remitted patients were experiencing attenuated positive symptoms (73%) and brief limited intermittent psychotic symptoms (18%), features that were similarly prevalent in the UHR group. There was no significant fluctuation in these low-level symptoms over the course of four interviews.

CONCLUSIONS: Although further research is required in this novel field, such features could form the building blocks for better prediction of psychotic relapse.

Original languageEnglish
Pages (from-to)296-9
Number of pages4
JournalEarly Intervention in Psychiatry
Volume3
Issue number4
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Adolescent
  • Adult
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Psychiatric Status Rating Scales/statistics & numerical data
  • Psychotic Disorders/complications
  • Remission Induction
  • Schizophrenia/complications
  • Schizophrenic Psychology

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