Script in a Day intervention for individuals who are injecting opioids: a feasibility randomized control trial

Angela M Beattie, Elsa M R Marques, Matthew Barber, Rosemary J Greenwood, Jenny C Ingram, Rachel Ayres, Jane Neale, Avril Rees, Barbara Coleman, Matt Hickman

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)
356 Downloads (Pure)


Background: Opioid substitution treatment (OST) reduces the harm of injecting and opioid dependence. The SCID feasibility trial explored the processes of conducting a randomized control trial (RCT) with people who inject drugs (PWID) in a low-threshold agency. Feasibility of the intervention investigated whether offering PWID immediate access to OST via specialist primary care increased numbers in OST at 3 months, compared with offering advice and case management.

Methods: Un-blinded RCT was conducted at Bristol Drugs Project needle exchange. A total of 311 individuals were eligible and 100 consented to participate. Trial process outcomes involved exploring OST status at 3 months; secondary outcomes were substance use and health-related quality of life measures.

Results: Follow-up was 86%. At 3 months, 51% intervention and 47% of control participants were in OST (OR of success of intervention 1.17 (0.54-2.57)). Opioid use reduced by 79 and 73%, respectively (OR of intervention success 1.38 (0.5-3.7)). Physical and mental health improved but there was little differences between groups.

Conclusions: The feasibility of conducting the trial was a success, but there was insufficient evidence of an effect compared with intensive case management. Further development and evaluation of case management approaches in low-threshold agencies is warranted.

Original languageEnglish
Pages (from-to)712-721
Number of pages10
JournalJournal of Public Health (United Kingdom)
Issue number4
Early online date29 Oct 2015
Publication statusPublished - 1 Dec 2016

Structured keywords

  • DECIPHer


  • opioid substitution treatment
  • people who inject drugs
  • primary care


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