Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis

H Hughes, DJ Stephens

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Abstract

Mitotic inhibition of COPII-dependent export of proteins from the endoplasmic reticulum results in disassembly of the Golgi complex. This ensures ordered inheritance of organelles by the two daughter cells. Reassembly of the Golgi is intimately linked to the re-initiation of ER export on exit from mitosis. Here, we show that unlike all other COPII components, which are cytosolic during metaphase, Sec16A remains associated with ER exit sites throughout mitosis, and thereby could provide a template for the rapid assembly of functional export domains in anaphase. Full assembly of COPII at exit sites precedes reassembly of the Golgi in telophase.
Translated title of the contributionSec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis
Original languageEnglish
Pages (from-to)4032 - 4038
Number of pages7
JournalJournal of Cell Science
Volume123 (23)
DOIs
Publication statusPublished - Dec 2010

Bibliographical note

Other: First published on-line November 2nd 2010

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