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Mitotic inhibition of COPII-dependent export of proteins from the endoplasmic reticulum results in disassembly of the Golgi complex. This ensures ordered inheritance of organelles by the two daughter cells. Reassembly of the Golgi is intimately linked to the re-initiation of ER export on exit from mitosis. Here, we show that unlike all other COPII components, which are cytosolic during metaphase, Sec16A remains associated with ER exit sites throughout mitosis, and thereby could provide a template for the rapid assembly of functional export domains in anaphase. Full assembly of COPII at exit sites precedes reassembly of the Golgi in telophase.
|Translated title of the contribution||Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis|
|Pages (from-to)||4032 - 4038|
|Number of pages||7|
|Journal||Journal of Cell Science|
|Publication status||Published - Dec 2010|
Bibliographical noteOther: First published on-line November 2nd 2010
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- 1 Finished
THE ROLE OF SEC16P IN THE ORGANIZATION AND FUNCTION OF MAMMALIAN ER EXPORT SITES
1/11/07 → 1/11/10