Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis

Brendan McIntosh, Chris Cameron, Sumeet R Singh, Changhua Yu, Tarun Ahuja, Nicky J Welton, Marshall Dahl

Research output: Contribution to journalArticle (Academic Journal)peer-review

103 Citations (Scopus)

Abstract

Although there is general agreement that metformin should be used as first-line pharmacotherapy in patients with type 2 diabetes, uncertainty remains regarding the choice of second-line therapy once metformin is no longer effective. We conducted a systematic review and meta-analysis to assess the comparative safety and efficacy of all available classes of antihyperglycemic therapies in patients with type 2 diabetes inadequately controlled on metformin monotherapy.
Original languageEnglish
Pages (from-to)e35-48
JournalOpen Medicine
Volume5
Issue number1
Publication statusPublished - 2011

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