Sedative and analgesic effects of buprenorphine, combined with either acepromazine or dexmedetomidine, for premedication prior to elective surgery in cats and dogs

James R Hunt, Nicola J Grint, Polly M Taylor, Joanna C Murrell

Research output: Contribution to journalArticle (Academic Journal)peer-review

32 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the sedative and analgesic effects of intramuscular buprenorphine with either dexmedetomidine or acepromazine, administered as premedication to cats and dogs undergoing elective surgery. STUDY DESIGN: Prospective, randomized, blinded clinical study. ANIMALS: Forty dogs and 48 cats. METHODS: Animals were assigned to one of four groups, according to anaesthetic premedication and induction agent: buprenorphine 20 μg kg(-1) with either dexmedetomidine (dex) 250 μg m(-2) or acepromazine (acp) 0.03 mg kg(-1) , followed by alfaxalone (ALF) or propofol (PRO). Meloxicam was administered preoperatively to all animals and anaesthesia was always maintained using isoflurane. Physiological measures and assessments of pain, sedation and mechanical nociceptive threshold (MNT) were made before and after premedication, intraoperatively, and for up to 24 hours after premedication. Data were analyzed with one-way, two-way and mixed between-within subjects anova, Kruskall-Wallis analyses and Chi squared tests. Results were deemed significant if p ≤ 0.05, except where multiple comparisons were performed (p ≤ 0.005). RESULTS: Cats premedicated with dex were more sedated than cats premedicated with acp (p 
Original languageEnglish
JournalVeterinary Anaesthesia and Analgesia
DOIs
Publication statusPublished - 2012

Bibliographical note

© 2012 The Authors. Veterinary Anaesthesia and Analgesia © 2012 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.

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