Selective inhibition from the anterior hypothalamus of C- vs A-fibre mediated spinal nociception

DAA Simpson, PM Headley, BM Lumb

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

Modulation of spinal nociception from the anterior hypothalamus/preoptic area (AH/POA), and consequent alterations in the pain experience may contribute to integrated responses brought into play during fear or stress and as part of the sickness response. This study was designed to compare the effects of descending control from AH/POA on A- versus C-fibre-evoked spinal nociception, since any differential control is of behavioural and clinical importance given that A-fibre and C-fibre nociceptors convey different qualities of the pain signal (first and second pain, respectively), and play different roles in the development and maintenance of chronic pain states. In anaesthetised rats, electromyographic responses were recorded to monitor thresholds of withdrawal to slow (2.5 degrees Cs(-1)) or fast (7.5 degrees Cs(-1)) rates of skin heating of the hindpaw, to preferentially activate C- or A-nociceptors, respectively. Neuronal activation by microinjection of dl-homocysteic acid at sites within a specific region of AH/POA, lateral area of the anterior hypothalamus (LAAH), significantly increased response thresholds to slow heating rates (p
Translated title of the contributionSelective inhibition from the anterior hypothalamus of C- vs A-fibre mediated spinal nociception
Original languageEnglish
Pages (from-to)305 - 312
Number of pages8
JournalPAIN
Volume136
DOIs
Publication statusPublished - Sep 2008

Bibliographical note

Publisher: ELSEVIER

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