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Selective Photothermal Killing of Cancer Cells Using LED-Activated Nucleus Targeting Fluorescent Carbon Dots

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Selective Photothermal Killing of Cancer Cells Using LED-Activated Nucleus Targeting Fluorescent Carbon Dots. / Hill, Stephen; Sheikh, Sadiyah; Zhang, Qiaoyu; Sueiro Ballesteros, Lorena; Herman, Andrew; Davies, Sean A.; Berry, Monica; Benito-Alifonso, David; Galan, Carmen.

In: Nanoscale Advances, Vol. 1, No. 8, 15.07.2019, p. 2840-2846 .

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Hill, Stephen ; Sheikh, Sadiyah ; Zhang, Qiaoyu ; Sueiro Ballesteros, Lorena ; Herman, Andrew ; Davies, Sean A. ; Berry, Monica ; Benito-Alifonso, David ; Galan, Carmen. / Selective Photothermal Killing of Cancer Cells Using LED-Activated Nucleus Targeting Fluorescent Carbon Dots. In: Nanoscale Advances. 2019 ; Vol. 1, No. 8. pp. 2840-2846 .

Bibtex

@article{b9b3afde1ef64e11b3ad545b930467f9,
title = "Selective Photothermal Killing of Cancer Cells Using LED-Activated Nucleus Targeting Fluorescent Carbon Dots",
abstract = "The development of effective theranostic probes in cancer therapy is hampered due to issues with selectivity and off-target toxicity. We report the selective LED-photothermal ablation of cervical (HeLa) cancer cells over human dermal fibroblasts (HDF) using a new class of green-emissive fluorescent carbon dots (FCDs). The FCDs can be easily prepared in one-pot using cheap and commercial starting materials. Physico-chemical characterization revealed that a surface coating of 2,5-deoxyfructosazine on a robust amorphous core renders the nanomaterial’s unique properties. We show that intracellular uptake mostly involves passive mechanisms in combination with intracellular DNA interactions to target the nucleus and that cancer cell selective killing is likely due to an increase in intracellular temperature in combination with ATP depletion, which is not observed upon of exposure to either the core FCD or the surface component individually. The selectivity of these nanoprobes and the lack of apparent production of toxic metabolic byproducts, makes these new nanomaterials promising agents in cancer therapy.",
author = "Stephen Hill and Sadiyah Sheikh and Qiaoyu Zhang and {Sueiro Ballesteros}, Lorena and Andrew Herman and Davies, {Sean A.} and Monica Berry and David Benito-Alifonso and Carmen Galan",
year = "2019",
month = "7",
day = "15",
doi = "10.1039/C9NA00293F",
language = "English",
volume = "1",
pages = "2840--2846",
journal = "Nanoscale Advances",
issn = "2516-0230",
publisher = "Royal Society of Chemistry",
number = "8",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Selective Photothermal Killing of Cancer Cells Using LED-Activated Nucleus Targeting Fluorescent Carbon Dots

AU - Hill, Stephen

AU - Sheikh, Sadiyah

AU - Zhang, Qiaoyu

AU - Sueiro Ballesteros, Lorena

AU - Herman, Andrew

AU - Davies, Sean A.

AU - Berry, Monica

AU - Benito-Alifonso, David

AU - Galan, Carmen

PY - 2019/7/15

Y1 - 2019/7/15

N2 - The development of effective theranostic probes in cancer therapy is hampered due to issues with selectivity and off-target toxicity. We report the selective LED-photothermal ablation of cervical (HeLa) cancer cells over human dermal fibroblasts (HDF) using a new class of green-emissive fluorescent carbon dots (FCDs). The FCDs can be easily prepared in one-pot using cheap and commercial starting materials. Physico-chemical characterization revealed that a surface coating of 2,5-deoxyfructosazine on a robust amorphous core renders the nanomaterial’s unique properties. We show that intracellular uptake mostly involves passive mechanisms in combination with intracellular DNA interactions to target the nucleus and that cancer cell selective killing is likely due to an increase in intracellular temperature in combination with ATP depletion, which is not observed upon of exposure to either the core FCD or the surface component individually. The selectivity of these nanoprobes and the lack of apparent production of toxic metabolic byproducts, makes these new nanomaterials promising agents in cancer therapy.

AB - The development of effective theranostic probes in cancer therapy is hampered due to issues with selectivity and off-target toxicity. We report the selective LED-photothermal ablation of cervical (HeLa) cancer cells over human dermal fibroblasts (HDF) using a new class of green-emissive fluorescent carbon dots (FCDs). The FCDs can be easily prepared in one-pot using cheap and commercial starting materials. Physico-chemical characterization revealed that a surface coating of 2,5-deoxyfructosazine on a robust amorphous core renders the nanomaterial’s unique properties. We show that intracellular uptake mostly involves passive mechanisms in combination with intracellular DNA interactions to target the nucleus and that cancer cell selective killing is likely due to an increase in intracellular temperature in combination with ATP depletion, which is not observed upon of exposure to either the core FCD or the surface component individually. The selectivity of these nanoprobes and the lack of apparent production of toxic metabolic byproducts, makes these new nanomaterials promising agents in cancer therapy.

U2 - 10.1039/C9NA00293F

DO - 10.1039/C9NA00293F

M3 - Article

VL - 1

SP - 2840

EP - 2846

JO - Nanoscale Advances

JF - Nanoscale Advances

SN - 2516-0230

IS - 8

ER -