SelEXSIDE: Fast and Easy Measurement of Multiple-Bond H-1,C-13 Coupling Constants for Stereochemical Analysis

Craig P. Butts; Bert Heise; Godiraone Tatolo

doi:10.1021/ol301078q

SelEXSIDE: Fast and Easy Measurement of Multiple-Bond H-1,C-13 Coupling Constants for Stereochemical Analysis

Craig P. Butts, Bert Heise, Godiraone Tatolo

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

Abstract

Long-range H-1,C-13 coupling constants ((n)J(CH)) are underutilized parameters for stereochemical structure determination, primarily because they are not easy to measure. This report describes a rapid and easily interpreted method for the measurement of one or more (n)J(CH) values based on a C-13 band-selective EXSIDE (SelEXSIDE), which reduces experiment times from many hours down to a few minutes while allowing a simple and straightforward readout of (n)J(CH) values from the resulting in-phase doublet signal.

Original language	English
Pages (from-to)	3256-3259
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	13
DOIs	https://doi.org/10.1021/ol301078q
Publication status	Published - 6 Jul 2012

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SelEXSIDE Pulse sequence
Butts, C. P. (Creator), University of Bristol, 6 May 2015
DOI: 10.5523/bris.xzopvpyrkkrk1fk1hx3e4x0k8, http://data.bris.ac.uk/data/dataset/xzopvpyrkkrk1fk1hx3e4x0k8
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title = "SelEXSIDE: Fast and Easy Measurement of Multiple-Bond H-1,C-13 Coupling Constants for Stereochemical Analysis",

abstract = "Long-range H-1,C-13 coupling constants ((n)J(CH)) are underutilized parameters for stereochemical structure determination, primarily because they are not easy to measure. This report describes a rapid and easily interpreted method for the measurement of one or more (n)J(CH) values based on a C-13 band-selective EXSIDE (SelEXSIDE), which reduces experiment times from many hours down to a few minutes while allowing a simple and straightforward readout of (n)J(CH) values from the resulting in-phase doublet signal.",

author = "Butts, {Craig P.} and Bert Heise and Godiraone Tatolo",

year = "2012",

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doi = "10.1021/ol301078q",

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volume = "14",

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journal = "Organic Letters",

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TY - JOUR

T1 - SelEXSIDE: Fast and Easy Measurement of Multiple-Bond H-1,C-13 Coupling Constants for Stereochemical Analysis

AU - Butts, Craig P.

AU - Heise, Bert

AU - Tatolo, Godiraone

PY - 2012/7/6

Y1 - 2012/7/6

N2 - Long-range H-1,C-13 coupling constants ((n)J(CH)) are underutilized parameters for stereochemical structure determination, primarily because they are not easy to measure. This report describes a rapid and easily interpreted method for the measurement of one or more (n)J(CH) values based on a C-13 band-selective EXSIDE (SelEXSIDE), which reduces experiment times from many hours down to a few minutes while allowing a simple and straightforward readout of (n)J(CH) values from the resulting in-phase doublet signal.

AB - Long-range H-1,C-13 coupling constants ((n)J(CH)) are underutilized parameters for stereochemical structure determination, primarily because they are not easy to measure. This report describes a rapid and easily interpreted method for the measurement of one or more (n)J(CH) values based on a C-13 band-selective EXSIDE (SelEXSIDE), which reduces experiment times from many hours down to a few minutes while allowing a simple and straightforward readout of (n)J(CH) values from the resulting in-phase doublet signal.

U2 - 10.1021/ol301078q

DO - 10.1021/ol301078q

M3 - Article (Academic Journal)

C2 - 22686446

SN - 1523-7060

VL - 14

SP - 3256

EP - 3259

JO - Organic Letters

JF - Organic Letters

IS - 13

ER -

SelEXSIDE: Fast and Easy Measurement of Multiple-Bond H-1,C-13 Coupling Constants for Stereochemical Analysis

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