TY - JOUR
T1 - Self-Assembled Magnetic Viruslike Particles for Encapsulation and Delivery of Deoxyribonucleic Acid
AU - Zhao, Wenrong
AU - Sun, Hong
AU - Wang, Yitong
AU - Eastoe, Julian
AU - Dong, Shuli
AU - Hao, Jingcheng
PY - 2018/6/19
Y1 - 2018/6/19
N2 - Developing nontoxic artificial carriers for stimuli-responsive capture, transport, and delivery of biomolecules is of immense scientific interest. Herein, for the first time, we synthesize a double-tailed cationic surfactant, (C16H33)2(CH3)2N+[FeCl3Br], which possesses magnetic properties [magnetic surfactants (Mag-Surfs)]. The time-dependent formation of virus-shaped hybrid mixed assemblies of polyoxometalates (POMs) {Mo72Fe30}/Mag-Surf with hollow-shell structures is followed. These structures serve well as robust high-surface-area shuttles, which can be manipulated with applied magnetic fields. By using cationic Mag-Surfs, the anionic POMs and DNA can be complexed in these ternary mixtures. These virus-shaped complexes act as nanoanchors and nanomotors, which can be utilized for binding, anchoring, and delivery of biomolecules, such as DNA. It is found that they have a good absorption capacity for DNA and myoglobin over 24 h, after application of a magnetic field. The realization of magnetic virus-shaped {Mo72Fe30}/Mag-Surf spheres may open possibilities for designing other functional nanoparticles, allowing effective control over the delivery/separation of biomolecules.
AB - Developing nontoxic artificial carriers for stimuli-responsive capture, transport, and delivery of biomolecules is of immense scientific interest. Herein, for the first time, we synthesize a double-tailed cationic surfactant, (C16H33)2(CH3)2N+[FeCl3Br], which possesses magnetic properties [magnetic surfactants (Mag-Surfs)]. The time-dependent formation of virus-shaped hybrid mixed assemblies of polyoxometalates (POMs) {Mo72Fe30}/Mag-Surf with hollow-shell structures is followed. These structures serve well as robust high-surface-area shuttles, which can be manipulated with applied magnetic fields. By using cationic Mag-Surfs, the anionic POMs and DNA can be complexed in these ternary mixtures. These virus-shaped complexes act as nanoanchors and nanomotors, which can be utilized for binding, anchoring, and delivery of biomolecules, such as DNA. It is found that they have a good absorption capacity for DNA and myoglobin over 24 h, after application of a magnetic field. The realization of magnetic virus-shaped {Mo72Fe30}/Mag-Surf spheres may open possibilities for designing other functional nanoparticles, allowing effective control over the delivery/separation of biomolecules.
UR - http://www.scopus.com/inward/record.url?scp=85048040788&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.8b01445
DO - 10.1021/acs.langmuir.8b01445
M3 - Article (Academic Journal)
C2 - 29809016
AN - SCOPUS:85048040788
SN - 0743-7463
VL - 34
SP - 7171
EP - 7179
JO - Langmuir
JF - Langmuir
IS - 24
ER -