Projects per year
An ability to mimic the boundaries of biological compartments would improve our understanding of self-assembly and provide routes to new materials for the delivery of drugs and biologicals and the development of protocells. We show that short designed peptides can be combined to form unilamellar spheres approximately 100 nanometers in diameter. The design comprises two, noncovalent, heterodimeric and homotrimeric coiled-coil bundles. These are joined back to back to render two complementary hubs, which when mixed form hexagonal networks that close to form cages. This design strategy offers control over chemistry, self-assembly, reversibility, and size of such particles.
|Number of pages||5|
|Publication status||Published - 3 May 2013|
- Bristol BioDesign Institute
- Protein Structure, Secondary
- Models, Molecular
- Protein Folding
- Circular Dichroism
- Molecular Dynamics Simulation
- Protein Multimerization
- Protein Conformation
- Microscopy, Electron, Scanning
- synthetic biology
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- 4 Finished
Development of supramolecular assemblies for enhancing cellular productivity and the synthesis of fine chemicals and biotheraputics.
Woolfson, D. N., Cryan, M. J. & Verkade, P.
1/10/14 → 30/09/19
Project: Research, Parent
3-month Core Capability for Chemistry Research
1/01/13 → 1/04/13
A BIOMOLECULAR-DESIGN APPROACH IN SYNTHETIC BIOLOGY: TOWARDS SYNTHETIC CYTOSKELETONS
1/07/09 → 1/07/13
HPC (High Performance Computing) Facility
Sadaf R Alam (Manager), Steven A Chapman (Manager), Polly E Eccleston (Other), Simon H Atack (Other) & D A G Williams (Manager)