Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation

Yufeng Chen, Yanwen Zhang, Mei Li, Songyang Liu, Xiaohai Yang, Kemin Wang, Stephen Mann, Jianbo Liu

Research output: Contribution to journalArticle (Academic Journal)peer-review


An artificial protocell model mimicking stimuli-triggered extracellular matrix formation is demonstrated based on the self-immobilization of coacervate microdroplets. Endogenous enzyme activity within the microdroplets results in the release of Ca2+ ions that trigger hydrogelation throughout the external environment, which in turn mechanically supports and chemically stabilizes the protocells.

Original languageEnglish
Pages (from-to)5438-5441
Number of pages4
JournalChemical communications (Cambridge, England)
Issue number44
Early online date5 May 2021
Publication statusPublished - 4 Jun 2021

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2021.


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