Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation

Yufeng Chen; Yanwen Zhang; Mei Li; Songyang Liu; Xiaohai Yang; Kemin Wang; Stephen Mann; Jianbo Liu

doi:10.1039/d1cc01483h

Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation

Yufeng Chen
, Yanwen Zhang
, Mei Li
, Songyang Liu
, Xiaohai Yang
, Kemin Wang
, Stephen Mann^*
, Jianbo Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

17 Citations (Scopus)

Abstract

An artificial protocell model mimicking stimuli-triggered extracellular matrix formation is demonstrated based on the self-immobilization of coacervate microdroplets. Endogenous enzyme activity within the microdroplets results in the release of Ca2+ ions that trigger hydrogelation throughout the external environment, which in turn mechanically supports and chemically stabilizes the protocells.

Original language	English
Pages (from-to)	5438-5441
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	44
Early online date	5 May 2021
DOIs	https://doi.org/10.1039/d1cc01483h
Publication status	Published - 4 Jun 2021

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2021.

Research Groups and Themes

Max Planck Bristol
Bristol BioDesign Institute
Inorganic & Materials

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title = "Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation",

abstract = "An artificial protocell model mimicking stimuli-triggered extracellular matrix formation is demonstrated based on the self-immobilization of coacervate microdroplets. Endogenous enzyme activity within the microdroplets results in the release of Ca2+ ions that trigger hydrogelation throughout the external environment, which in turn mechanically supports and chemically stabilizes the protocells.",

author = "Yufeng Chen and Yanwen Zhang and Mei Li and Songyang Liu and Xiaohai Yang and Kemin Wang and Stephen Mann and Jianbo Liu",

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doi = "10.1039/d1cc01483h",

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T1 - Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation

AU - Chen, Yufeng

AU - Zhang, Yanwen

AU - Li, Mei

AU - Liu, Songyang

AU - Yang, Xiaohai

AU - Wang, Kemin

AU - Mann, Stephen

AU - Liu, Jianbo

PY - 2021/6/4

Y1 - 2021/6/4

N2 - An artificial protocell model mimicking stimuli-triggered extracellular matrix formation is demonstrated based on the self-immobilization of coacervate microdroplets. Endogenous enzyme activity within the microdroplets results in the release of Ca2+ ions that trigger hydrogelation throughout the external environment, which in turn mechanically supports and chemically stabilizes the protocells.

AB - An artificial protocell model mimicking stimuli-triggered extracellular matrix formation is demonstrated based on the self-immobilization of coacervate microdroplets. Endogenous enzyme activity within the microdroplets results in the release of Ca2+ ions that trigger hydrogelation throughout the external environment, which in turn mechanically supports and chemically stabilizes the protocells.

U2 - 10.1039/d1cc01483h

DO - 10.1039/d1cc01483h

M3 - Article (Academic Journal)

C2 - 33949484

SN - 1359-7345

VL - 57

SP - 5438

EP - 5441

JO - Chemical Communications

JF - Chemical Communications

IS - 44

ER -

Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation

Abstract

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