Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: Historical cohort study

Stanley Zammit*, Peter Allebeck, Sven Andreasson, Ingvar Lundberg, Glyn Lewis

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

627 Citations (Scopus)

Abstract

Objectives: An association between use of cannabis in adolescence and subsequent risk of schizophrenia was previously reported in a follow up of Swedish conscripts. Arguments were raised that this association may be due to use of drugs other than cannabis and that personality traits may have confounded results. We performed a further analysis of this cohort to address these uncertainties while extending the follow up period to identify additional cases. Design: Historical cohort study. Setting: 1969-70 survey of Swedish conscripts ( > 97% of the country's male population aged 18-20). Participants: 50 087 subjects: data were available on self reported use of cannabis and other drugs, and on several social and psychological characteristics. Main outcome measures: Admissions to hospital for ICD-8/9 schizophrenia and other psychoses, as determined by record linkage. Results: Cannabis was associated with an increased risk of developing schizophrenia in a dose dependent fashion both for subjects who had ever used cannabis (adjusted odds ratio for linear trend of increasing frequency 1.2, 95% confidence interval 1.1 to 1.4, P <0.001), and for subjects who had used only cannabis and no other drugs (adjusted odds ratio for linear trend 1.3, 1.1 to 1.5, P <0.015). The adjusted odds ratio for using cannabis > 50 times was 6.7 (2.1 to 21.7) in the cannabis only group. Similar results were obtained when analysis was restricted to subjects developing schizophrenia after five years after conscription, to exclude prodromal cases. Conclusions: Cannabis use is associated with an increased risk of developing schizophrenia, consistent with a causal relation. This association is not explained by use of other psychoactive drugs or personality traits relating to social integration.

Original languageEnglish
Pages (from-to)1199-1201
Number of pages3
JournalBMJ
Volume325
Issue number7374
DOIs
Publication statusPublished - 23 Nov 2002

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