Sensing change: The emerging role of calcium sensors in neuronal disease

Gillian Seaton, Ellen L. Hogg, Jihoon Jo, Daniel J. Whitcomb*, Kei Cho

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

16 Citations (Scopus)

Abstract

Calcium (Ca 2+) is a fundamental intracellular signalling molecule in neurons. Therefore, significant interest has been expressed in understanding how the dysregulation of Ca 2+ signals might impact on neuronal function and the progression of different disease states. Many previous studies have examined the role of Ca 2+ in neuronal excitotoxicity and some have started to understand how Ca 2+ dysregulation might be a cause or consequence of neurodegeneration. This review will therefore focus on the significance of Ca 2+ sensors, proteins that transduce Ca 2+ signals, in neuronal function and dysfunction. Finally, we will assess their potential role in neurodegenerative processes, such as Alzheimer's disease (AD), arguing that they could serve as potential therapeutic targets.

Original languageEnglish
Pages (from-to)530-535
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number5
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Alzheimer's disease
  • Calcium
  • Calcium sensors
  • Neurodegenerative disease
  • Synaptic plasticity

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