Physically based projections of the Greenland ice sheet contribution to future sea-level change are subject to uncertainties of the atmospheric and oceanic climatic forcing and to the formulations within the ice flow model itself. Here a higher-order, three-dimensional thermomechanical ice flow model is used, initialized to the present-day geometry. The forcing comes from a high-resolution regional climate model and from a flowline model applied to four individual marine-terminated glaciers, and results are subsequently extended to the entire ice sheet. The experiments span the next 200 years and consider climate scenario SRES A1B. The surface mass-balance (SMB) scheme is taken either from a regional climate model or from a positive-degree-day (PDD) model using temperature and precipitation anomalies from the underlying climate models. Our model results show that outlet glacier dynamics only account for 6–18% of the sea-level contribution after 200 years, confirming earlier findings that stress the dominant effect of SMB changes. Furthermore, interaction between SMB and ice discharge limits the importance of outlet glacier dynamics with increasing atmospheric forcing. Forcing from the regional climate model produces a 14–31% higher sea-level contribution compared to a PDD model run with the same parameters as for IPCC AR4.