Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure

Frank de Vocht*, Igor Burstyn, Gilles Ferro, Ann Olsson, Mia Hashibe, Hans Kromhout, Paolo Boffetta

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)

Abstract

A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations.

New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated.

The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure.

The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.

Original languageEnglish
Pages (from-to)723-733
Number of pages11
JournalInternational Archives of Occupational and Environmental Health
Volume82
Issue number6
DOIs
Publication statusPublished - May 2009

Keywords

  • Asphalt industry
  • Asphalt paving
  • Exposure assessment
  • Bitumen fume
  • Sensitivity analysis
  • POLYCYCLIC AROMATIC-HYDROCARBONS
  • EUROPEAN ASPHALT WORKERS
  • MAGNETIC-FIELD EXPOSURE
  • OCCUPATIONAL EPIDEMIOLOGY
  • PAVING WORKERS
  • MORTALITY
  • INDUSTRY
  • DETERMINANTS
  • METAANALYSIS
  • VARIABILITY

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