Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure

Frank de Vocht; Igor Burstyn; Gilles Ferro; Ann Olsson; Mia Hashibe; Hans Kromhout; Paolo Boffetta

doi:10.1007/s00420-008-0373-6

Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure

Frank de Vocht^*, Igor Burstyn, Gilles Ferro, Ann Olsson, Mia Hashibe, Hans Kromhout, Paolo Boffetta

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

Abstract

A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations.

New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated.

The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure.

The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.

Original language	English
Pages (from-to)	723-733
Number of pages	11
Journal	International Archives of Occupational and Environmental Health
Volume	82
Issue number	6
DOIs	https://doi.org/10.1007/s00420-008-0373-6
Publication status	Published - May 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Asphalt industry
Asphalt paving
Exposure assessment
Bitumen fume
Sensitivity analysis
POLYCYCLIC AROMATIC-HYDROCARBONS
EUROPEAN ASPHALT WORKERS
MAGNETIC-FIELD EXPOSURE
OCCUPATIONAL EPIDEMIOLOGY
PAVING WORKERS
MORTALITY
INDUSTRY
DETERMINANTS
METAANALYSIS
VARIABILITY

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@article{747add45ce0c489b8f45394fd8becd95,

title = "Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure",

abstract = "A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations.New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated.The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7\% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure.The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.",

keywords = "Asphalt industry, Asphalt paving, Exposure assessment, Bitumen fume, Sensitivity analysis, POLYCYCLIC AROMATIC-HYDROCARBONS, EUROPEAN ASPHALT WORKERS, MAGNETIC-FIELD EXPOSURE, OCCUPATIONAL EPIDEMIOLOGY, PAVING WORKERS, MORTALITY, INDUSTRY, DETERMINANTS, METAANALYSIS, VARIABILITY",

author = "\{de Vocht\}, Frank and Igor Burstyn and Gilles Ferro and Ann Olsson and Mia Hashibe and Hans Kromhout and Paolo Boffetta",

year = "2009",

month = may,

doi = "10.1007/s00420-008-0373-6",

language = "English",

volume = "82",

pages = "723--733",

journal = "International Archives of Occupational and Environmental Health",

issn = "0340-0131",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "6",

}

Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure. / de Vocht, Frank; Burstyn, Igor; Ferro, Gilles et al.
In: International Archives of Occupational and Environmental Health, Vol. 82, No. 6, 05.2009, p. 723-733.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure

AU - de Vocht, Frank

AU - Burstyn, Igor

AU - Ferro, Gilles

AU - Olsson, Ann

AU - Hashibe, Mia

AU - Kromhout, Hans

AU - Boffetta, Paolo

PY - 2009/5

Y1 - 2009/5

N2 - A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations.New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated.The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure.The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.

AB - A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations.New exposure estimates were generated by changing assumptions on exposure levels, specific tasks, lags, and coal tar use. Subsequently, Poisson regression models estimated relative risks (RRs); change in fit of models was evaluated.The influence of these assumptions was minimal, with log-likelihood deviations between -5.0 and 4.7% and similar patterns in dose-dependent increases of lung cancer risk. In the highest exposure categories, point estimates of RRs ranged 2.07-2.83 for average, and 1.22-2.23 for cumulative exposure.The small increase in lung cancer risk associated with bitumen fume exposure depends only to a limited extent on the subjective judgments made in the exposure assessment for this cohort.

KW - Asphalt industry

KW - Asphalt paving

KW - Exposure assessment

KW - Bitumen fume

KW - Sensitivity analysis

KW - POLYCYCLIC AROMATIC-HYDROCARBONS

KW - EUROPEAN ASPHALT WORKERS

KW - MAGNETIC-FIELD EXPOSURE

KW - OCCUPATIONAL EPIDEMIOLOGY

KW - PAVING WORKERS

KW - MORTALITY

KW - INDUSTRY

KW - DETERMINANTS

KW - METAANALYSIS

KW - VARIABILITY

U2 - 10.1007/s00420-008-0373-6

DO - 10.1007/s00420-008-0373-6

M3 - Article (Academic Journal)

C2 - 18956211

SN - 0340-0131

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SP - 723

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JO - International Archives of Occupational and Environmental Health

JF - International Archives of Occupational and Environmental Health

IS - 6

ER -

Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure

Abstract

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Keywords

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