Skip to content

Separate elements of episodic memory subserved by distinct hippocampal-prefrontal connections

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)242–250
Number of pages11
JournalNature Neuroscience
Issue number2
Early online date9 Jan 2017
DateAccepted/In press - 1 Dec 2016
DateE-pub ahead of print - 9 Jan 2017
DatePublished (current) - Feb 2017


Episodic memory formation depends on information about a stimulus being integrated within a precise spatial and temporal context, a process dependent on the hippocampus and prefrontal cortex. Investigations of putative functional interactions between these regions are complicated by multiple direct and indirect hippocampal-prefrontal connections. Here application of a pharmaco-genetic deactivation technique enabled an investigation of the mnemonic contributions of two direct hippocampal-medial prefrontal cortex (mPFC) pathways; one arising in the dorsal CA1 (dCA1), the other in the intermediate CA1 (iCA1). While, deactivation of either pathway impaired episodic memory, the resulting pattern of mnemonic deficits was significantly different; deactivation of the dCA1→mPFC pathway selecƟvely disrupted temporal order judgements, while iCA1→mPFC pathway deactivation disrupted spatial memory. These findings reveal a major, previously unsuspected division of function among A1 neurons that project directly to the mPFC. Such sub-networks may enable the distinctiveness of contextual information to be maintained within an episodic memory circuit.

Download statistics

No data available



  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature at Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 40.1 MB, PDF document


View research connections

Related faculties, schools or groups