Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

M Parkes; JC Barrett; NJ Prescott; M Tremelling; CA Anderson; SA Fisher; RG Roberts; ER Nimmo; FR Cummings; D Soars; CW Lees; SA Khawaja; R Bagnall; DA Burke; CE Todhunter; T Ahmad; CM Onnie; W L McArdle; D Strachan; G Bethel; C Bryan; CM Lewis; P Deloukas; A Forbes; J Sanderson; DP Jewell; J Satsangi; JC Mansfield; Consortium The Wellcome Trust Case Control; D Evans; L Cardon; CG Mathew

doi:10.1038/ng2061

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

M Parkes, JC Barrett, NJ Prescott, M Tremelling, CA Anderson, SA Fisher, RG Roberts, ER Nimmo, FR Cummings, D Soars, CW Lees, SA Khawaja, R Bagnall, DA Burke, CE Todhunter, T Ahmad, CM Onnie, W L McArdle, D Strachan, G BethelC Bryan, CM Lewis, P Deloukas, A Forbes, J Sanderson, DP Jewell, J Satsangi, JC Mansfield, Consortium The Wellcome Trust Case Control, D Evans, L Cardon, CG Mathew

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1006 Citations (Scopus)

Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

Translated title of the contribution	Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Original language	English
Pages (from-to)	830-2
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	7
DOIs	https://doi.org/10.1038/ng2061
Publication status	Published - 2007

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Publisher: Nature Pub. Co

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Parkes, M., Barrett, JC., Prescott, NJ., Tremelling, M., Anderson, CA., Fisher, SA., Roberts, RG., Nimmo, ER., Cummings, FR., Soars, D., Lees, CW., Khawaja, SA., Bagnall, R., Burke, DA., Todhunter, CE., Ahmad, T., Onnie, CM., McArdle, W. L., Strachan, D., ... Mathew, CG. (2007). Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genetics, 39(7), 830-2. https://doi.org/10.1038/ng2061

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title = "Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility",

abstract = "A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.",

author = "M Parkes and JC Barrett and NJ Prescott and M Tremelling and CA Anderson and SA Fisher and RG Roberts and ER Nimmo and FR Cummings and D Soars and CW Lees and SA Khawaja and R Bagnall and DA Burke and CE Todhunter and T Ahmad and CM Onnie and McArdle, {W L} and D Strachan and G Bethel and C Bryan and CM Lewis and P Deloukas and A Forbes and J Sanderson and DP Jewell and J Satsangi and JC Mansfield and {The Wellcome Trust Case Control}, Consortium and D Evans and L Cardon and CG Mathew",

note = "Publisher: Nature Pub. Co",

year = "2007",

doi = "10.1038/ng2061",

language = "English",

volume = "39",

pages = "830--2",

journal = "Nature Genetics",

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Parkes, M, Barrett, JC, Prescott, NJ, Tremelling, M, Anderson, CA, Fisher, SA, Roberts, RG, Nimmo, ER, Cummings, FR, Soars, D, Lees, CW, Khawaja, SA, Bagnall, R, Burke, DA, Todhunter, CE, Ahmad, T, Onnie, CM, McArdle, WL, Strachan, D, Bethel, G, Bryan, C, Lewis, CM, Deloukas, P, Forbes, A, Sanderson, J, Jewell, DP, Satsangi, J, Mansfield, JC, The Wellcome Trust Case Control, C, Evans, D, Cardon, L & Mathew, CG 2007, 'Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility', Nature Genetics, vol. 39, no. 7, pp. 830-2. https://doi.org/10.1038/ng2061

TY - JOUR

T1 - Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

AU - Parkes, M

AU - Barrett, JC

AU - Prescott, NJ

AU - Tremelling, M

AU - Anderson, CA

AU - Fisher, SA

AU - Roberts, RG

AU - Nimmo, ER

AU - Cummings, FR

AU - Soars, D

AU - Lees, CW

AU - Khawaja, SA

AU - Bagnall, R

AU - Burke, DA

AU - Todhunter, CE

AU - Ahmad, T

AU - Onnie, CM

AU - McArdle, W L

AU - Strachan, D

AU - Bethel, G

AU - Bryan, C

AU - Lewis, CM

AU - Deloukas, P

AU - Forbes, A

AU - Sanderson, J

AU - Jewell, DP

AU - Satsangi, J

AU - Mansfield, JC

AU - The Wellcome Trust Case Control, Consortium

AU - Evans, D

AU - Cardon, L

AU - Mathew, CG

N1 - Publisher: Nature Pub. Co

PY - 2007

Y1 - 2007

N2 - A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

AB - A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

U2 - 10.1038/ng2061

DO - 10.1038/ng2061

M3 - Article (Academic Journal)

C2 - 17554261

SN - 1546-1718

VL - 39

SP - 830

EP - 832

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Abstract

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