Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

M Parkes, JC Barrett, NJ Prescott, M Tremelling, CA Anderson, SA Fisher, RG Roberts, ER Nimmo, FR Cummings, D Soars, CW Lees, SA Khawaja, R Bagnall, DA Burke, CE Todhunter, T Ahmad, CM Onnie, W L McArdle, D Strachan, G BethelC Bryan, CM Lewis, P Deloukas, A Forbes, J Sanderson, DP Jewell, J Satsangi, JC Mansfield, Consortium The Wellcome Trust Case Control, D Evans, L Cardon, CG Mathew

Research output: Contribution to journalArticle (Academic Journal)peer-review

903 Citations (Scopus)

Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
Translated title of the contributionSequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Original languageEnglish
Pages (from-to)830-2
Number of pages3
JournalNature Genetics
Volume39
Issue number7
DOIs
Publication statusPublished - 2007

Bibliographical note

Publisher: Nature Pub. Co

Fingerprint

Dive into the research topics of 'Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility'. Together they form a unique fingerprint.

Cite this