Sequential acquisition of T-cells and antibodies to nontyphoidal Salmonella in Malawian Children

Tonney S Nyirenda, James J Gilchrist, Nicholas A Feasey, Sarah J Glennie, Naor Bar-Zeev, Melita A Gordon, Calman A Maclennan, Wilson L Mandala, Robert S Heyderman

Research output: Contribution to journalArticle (Academic Journal)peer-review

29 Citations (Scopus)

Abstract

Background. S. Typhimurium (STm) remain a prominent cause of bacteremia in sub-Saharan Africa. Complement-fixing antibodies to STm develop by 2 years of age. We hypothesized that STm-specific CD4+ T cells develop alongside this process.Methods. Eighty healthy Malawian children aged 0-60 months were recruited. STm-specific CD4+ T cells producing IFNγ, TNFα and IL2 were quantified using intra-cellular cytokine staining. Antibodies to STm were measured by serum bactericidal activity assay (SBA), and anti-STm IgG antibodies by ELISA.Results. Between 2006 and 2011, 449 STm bacteremias were detected in children
Original languageEnglish
JournalJournal of Infectious Diseases
DOIs
Publication statusPublished - 16 Jan 2014

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