Seroprevalence of Bactericidal, Specific IgG Antibodies and Incidence of Meningitis Due to Group A Neisseria meningitidis by Age in Burkina Faso 2008

Caroline L. Trotter; Seydou Yaro; Berthe-Marie Njanpop-Lafourcade; Aly Drabo; Sita S. Kroman; Regina S. Idohou; Oumarou Sanou; Leah Bowen; Helen Findlow; Serge Diagbouga; Bradford D. Gessner; Ray Borrow; Judith E. Mueller

doi:10.1371/journal.pone.0055486

Seroprevalence of Bactericidal, Specific IgG Antibodies and Incidence of Meningitis Due to Group A Neisseria meningitidis by Age in Burkina Faso 2008

Caroline L. Trotter^*, Seydou Yaro, Berthe-Marie Njanpop-Lafourcade, Aly Drabo, Sita S. Kroman, Regina S. Idohou, Oumarou Sanou, Leah Bowen, Helen Findlow, Serge Diagbouga, Bradford D. Gessner, Ray Borrow, Judith E. Mueller

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Background: We investigated serological correlates of protection against Neisseria meningitidis serogroup A (NmA) in Burkina Faso before the introduction of NmA conjugate vaccine.

Methodology/Principal Findings: We collected blood from a representative sample (N = 1022) of Bobo-Dioulasso residents. Sera were evaluated for serum bactericidal antibody (SBA) activity against NmA strains of immunotype L11 (F8238) and L10 (3125) and NmA-specific IgG. Seroprevalence was compared to the age-specific NmA meningitis incidence in Bobo-Dioulasso during March 2007-February 2008. Meningococcal carriage was evaluated in a subset (N = 538). Geometric mean titres (GMT)/concentrations (GMC) of SBA and NmA-specific IgG increased with age, peaking around age 20 years. Overall, 70% of our sample had NmA-specific IgG >= 2 ug/mL. Meningitis incidence was highest in those aged

Conclusions/Significance: This study provides estimates of natural immunity to NmA, according to a variety of antibody measures, which will be helpful in ascertaining antibody persistence after MenAfriVac (TM) introduction. Age-specific seroprevalence of reference strain SBA titres most likely reflects exposure to meningococci and consecutive reactive immunity. We could not define any serological correlate of protection.

Original language	English
Article number	55486
Number of pages	8
Journal	PLoS ONE
Volume	8
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0055486
Publication status	Published - 14 Feb 2013

Keywords

MENINGOCOCCAL MENINGITIS
SEROGROUP-C
CAPSULAR POLYSACCHARIDE
IMMUNITY
VACCINES
ENGLAND
CARRIAGE
EPIDEMIC
BELT
VACCINATION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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REVISED - SEROEPIDEMIOLOGY AND CORRELATES OF PROTECTION FOR NEISSERIA MENINGITIDIS GROUP A IN THE AFRICAN MENINGITIS BELT
Trotter, C. L. (Principal Investigator)
1/03/08 → 1/09/09
Project: Research

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Trotter, C. L., Yaro, S., Njanpop-Lafourcade, B.-M., Drabo, A., Kroman, S. S., Idohou, R. S., Sanou, O., Bowen, L., Findlow, H., Diagbouga, S., Gessner, B. D., Borrow, R., & Mueller, J. E. (2013). Seroprevalence of Bactericidal, Specific IgG Antibodies and Incidence of Meningitis Due to Group A Neisseria meningitidis by Age in Burkina Faso 2008. PLoS ONE, 8(2), Article 55486. https://doi.org/10.1371/journal.pone.0055486

@article{4194cc7970d343e4b3201b00916979f4,

title = "Seroprevalence of Bactericidal, Specific IgG Antibodies and Incidence of Meningitis Due to Group A Neisseria meningitidis by Age in Burkina Faso 2008",

abstract = "Background: We investigated serological correlates of protection against Neisseria meningitidis serogroup A (NmA) in Burkina Faso before the introduction of NmA conjugate vaccine.Methodology/Principal Findings: We collected blood from a representative sample (N = 1022) of Bobo-Dioulasso residents. Sera were evaluated for serum bactericidal antibody (SBA) activity against NmA strains of immunotype L11 (F8238) and L10 (3125) and NmA-specific IgG. Seroprevalence was compared to the age-specific NmA meningitis incidence in Bobo-Dioulasso during March 2007-February 2008. Meningococcal carriage was evaluated in a subset (N = 538). Geometric mean titres (GMT)/concentrations (GMC) of SBA and NmA-specific IgG increased with age, peaking around age 20 years. Overall, 70% of our sample had NmA-specific IgG >= 2 ug/mL. Meningitis incidence was highest in those aged Conclusions/Significance: This study provides estimates of natural immunity to NmA, according to a variety of antibody measures, which will be helpful in ascertaining antibody persistence after MenAfriVac (TM) introduction. Age-specific seroprevalence of reference strain SBA titres most likely reflects exposure to meningococci and consecutive reactive immunity. We could not define any serological correlate of protection.",

keywords = "MENINGOCOCCAL MENINGITIS, SEROGROUP-C, CAPSULAR POLYSACCHARIDE, IMMUNITY, VACCINES, ENGLAND, CARRIAGE, EPIDEMIC, BELT, VACCINATION",

author = "Trotter, {Caroline L.} and Seydou Yaro and Berthe-Marie Njanpop-Lafourcade and Aly Drabo and Kroman, {Sita S.} and Idohou, {Regina S.} and Oumarou Sanou and Leah Bowen and Helen Findlow and Serge Diagbouga and Gessner, {Bradford D.} and Ray Borrow and Mueller, {Judith E.}",

year = "2013",

month = feb,

day = "14",

doi = "10.1371/journal.pone.0055486",

language = "English",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "2",

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Trotter, CL, Yaro, S, Njanpop-Lafourcade, B-M, Drabo, A, Kroman, SS, Idohou, RS, Sanou, O, Bowen, L, Findlow, H, Diagbouga, S, Gessner, BD, Borrow, R & Mueller, JE 2013, 'Seroprevalence of Bactericidal, Specific IgG Antibodies and Incidence of Meningitis Due to Group A Neisseria meningitidis by Age in Burkina Faso 2008', PLoS ONE, vol. 8, no. 2, 55486. https://doi.org/10.1371/journal.pone.0055486

TY - JOUR

T1 - Seroprevalence of Bactericidal, Specific IgG Antibodies and Incidence of Meningitis Due to Group A Neisseria meningitidis by Age in Burkina Faso 2008

AU - Trotter, Caroline L.

AU - Yaro, Seydou

AU - Njanpop-Lafourcade, Berthe-Marie

AU - Drabo, Aly

AU - Kroman, Sita S.

AU - Idohou, Regina S.

AU - Sanou, Oumarou

AU - Bowen, Leah

AU - Findlow, Helen

AU - Diagbouga, Serge

AU - Gessner, Bradford D.

AU - Borrow, Ray

AU - Mueller, Judith E.

PY - 2013/2/14

Y1 - 2013/2/14

N2 - Background: We investigated serological correlates of protection against Neisseria meningitidis serogroup A (NmA) in Burkina Faso before the introduction of NmA conjugate vaccine.Methodology/Principal Findings: We collected blood from a representative sample (N = 1022) of Bobo-Dioulasso residents. Sera were evaluated for serum bactericidal antibody (SBA) activity against NmA strains of immunotype L11 (F8238) and L10 (3125) and NmA-specific IgG. Seroprevalence was compared to the age-specific NmA meningitis incidence in Bobo-Dioulasso during March 2007-February 2008. Meningococcal carriage was evaluated in a subset (N = 538). Geometric mean titres (GMT)/concentrations (GMC) of SBA and NmA-specific IgG increased with age, peaking around age 20 years. Overall, 70% of our sample had NmA-specific IgG >= 2 ug/mL. Meningitis incidence was highest in those aged Conclusions/Significance: This study provides estimates of natural immunity to NmA, according to a variety of antibody measures, which will be helpful in ascertaining antibody persistence after MenAfriVac (TM) introduction. Age-specific seroprevalence of reference strain SBA titres most likely reflects exposure to meningococci and consecutive reactive immunity. We could not define any serological correlate of protection.

AB - Background: We investigated serological correlates of protection against Neisseria meningitidis serogroup A (NmA) in Burkina Faso before the introduction of NmA conjugate vaccine.Methodology/Principal Findings: We collected blood from a representative sample (N = 1022) of Bobo-Dioulasso residents. Sera were evaluated for serum bactericidal antibody (SBA) activity against NmA strains of immunotype L11 (F8238) and L10 (3125) and NmA-specific IgG. Seroprevalence was compared to the age-specific NmA meningitis incidence in Bobo-Dioulasso during March 2007-February 2008. Meningococcal carriage was evaluated in a subset (N = 538). Geometric mean titres (GMT)/concentrations (GMC) of SBA and NmA-specific IgG increased with age, peaking around age 20 years. Overall, 70% of our sample had NmA-specific IgG >= 2 ug/mL. Meningitis incidence was highest in those aged Conclusions/Significance: This study provides estimates of natural immunity to NmA, according to a variety of antibody measures, which will be helpful in ascertaining antibody persistence after MenAfriVac (TM) introduction. Age-specific seroprevalence of reference strain SBA titres most likely reflects exposure to meningococci and consecutive reactive immunity. We could not define any serological correlate of protection.

KW - MENINGOCOCCAL MENINGITIS

KW - SEROGROUP-C

KW - CAPSULAR POLYSACCHARIDE

KW - IMMUNITY

KW - VACCINES

KW - ENGLAND

KW - CARRIAGE

KW - EPIDEMIC

KW - BELT

KW - VACCINATION

U2 - 10.1371/journal.pone.0055486

DO - 10.1371/journal.pone.0055486

M3 - Article (Academic Journal)

C2 - 23457471

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 2

M1 - 55486

ER -

Seroprevalence of Bactericidal, Specific IgG Antibodies and Incidence of Meningitis Due to Group A Neisseria meningitidis by Age in Burkina Faso 2008

Abstract

Keywords

UN SDGs

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REVISED - SEROEPIDEMIOLOGY AND CORRELATES OF PROTECTION FOR NEISSERIA MENINGITIDIS GROUP A IN THE AFRICAN MENINGITIS BELT

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