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Background: We investigated serological correlates of protection against Neisseria meningitidis serogroup A (NmA) in Burkina Faso before the introduction of NmA conjugate vaccine.
Methodology/Principal Findings: We collected blood from a representative sample (N = 1022) of Bobo-Dioulasso residents. Sera were evaluated for serum bactericidal antibody (SBA) activity against NmA strains of immunotype L11 (F8238) and L10 (3125) and NmA-specific IgG. Seroprevalence was compared to the age-specific NmA meningitis incidence in Bobo-Dioulasso during March 2007-February 2008. Meningococcal carriage was evaluated in a subset (N = 538). Geometric mean titres (GMT)/concentrations (GMC) of SBA and NmA-specific IgG increased with age, peaking around age 20 years. Overall, 70% of our sample had NmA-specific IgG >= 2 ug/mL. Meningitis incidence was highest in those aged
Conclusions/Significance: This study provides estimates of natural immunity to NmA, according to a variety of antibody measures, which will be helpful in ascertaining antibody persistence after MenAfriVac (TM) introduction. Age-specific seroprevalence of reference strain SBA titres most likely reflects exposure to meningococci and consecutive reactive immunity. We could not define any serological correlate of protection.
- MENINGOCOCCAL MENINGITIS
- CAPSULAR POLYSACCHARIDE
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- 1 Finished
REVISED - SEROEPIDEMIOLOGY AND CORRELATES OF PROTECTION FOR NEISSERIA MENINGITIDIS GROUP A IN THE AFRICAN MENINGITIS BELT
Trotter, C. L.
1/03/08 → 1/09/09