Seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso

CL Trotter; JE Mueller; S Yaro; BM Njanpop-Lafourcade; A Drabo; SP Diagbouga; RS Idohou; L Bowen; P Nicolas; H Findlow; R Borrow

Seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso

CL Trotter, JE Mueller, S Yaro, BM Njanpop-Lafourcade, A Drabo, SP Diagbouga, RS Idohou, L Bowen, P Nicolas, H Findlow, R Borrow

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Abstract

Aim To describe the age-specific seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso during the meningitis season of 2008 (non-epidemic year). Methods In February and March 2008, a representative sample of residents of urban Bobo-Dioulasso, Burkina Faso aged 0–59 years participated in a meningococcal seroprevalence (N=1008) and carriage (N=500) study. Serum bactericidal antibody (SBA) titres to strain F8238 (A:4:P1.20,9) were determined using standard methods (rabbit complement). Results The geometric mean titres (GMT) and prevalence of titres ≥8 varied substantially with age. In infants, only 4/107 (4%) had SBA titres >4, but 60% of 1-4 year olds had SBA titres ≥8. Both the GMTs and proportion with SBA titres ≥8 increased in each subsequent age group, peaking in 20-24 year olds (GMT = 488μg/ml, 90% with SBA titre ≥8) before declining in older adults. Provisional results indicate that overall meningococcal carriage prevalence was low (30 years [see abstract by Yaro et al.] The classic Goldschneider curves cannot be replicated in this population, with both high SBA titres and high (hyper-)endemic disease incidence being reported in individuals aged 5-29 years. The absence of detectable serogroup A carriage suggests that exposure to other organisms may induce serum bactericidal activity.

Translated title of the contribution	Seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso
Original language	English
Title of host publication	10th Meeting of the EMGM European Meningococcal Disease Society, Manchester, UK
Publication status	Published - Jun 2009

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@inproceedings{d8600825fdab448eba917391d90efd56,

title = "Seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso",

abstract = "Aim To describe the age-specific seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso during the meningitis season of 2008 (non-epidemic year). Methods In February and March 2008, a representative sample of residents of urban Bobo-Dioulasso, Burkina Faso aged 0–59 years participated in a meningococcal seroprevalence (N=1008) and carriage (N=500) study. Serum bactericidal antibody (SBA) titres to strain F8238 (A:4:P1.20,9) were determined using standard methods (rabbit complement). Results The geometric mean titres (GMT) and prevalence of titres ≥8 varied substantially with age. In infants, only 4/107 (4%) had SBA titres >4, but 60% of 1-4 year olds had SBA titres ≥8. Both the GMTs and proportion with SBA titres ≥8 increased in each subsequent age group, peaking in 20-24 year olds (GMT = 488μg/ml, 90% with SBA titre ≥8) before declining in older adults. Provisional results indicate that overall meningococcal carriage prevalence was low (30 years [see abstract by Yaro et al.] The classic Goldschneider curves cannot be replicated in this population, with both high SBA titres and high (hyper-)endemic disease incidence being reported in individuals aged 5-29 years. The absence of detectable serogroup A carriage suggests that exposure to other organisms may induce serum bactericidal activity.",

author = "CL Trotter and JE Mueller and S Yaro and BM Njanpop-Lafourcade and A Drabo and SP Diagbouga and RS Idohou and L Bowen and P Nicolas and H Findlow and R Borrow",

year = "2009",

month = jun,

language = "English",

booktitle = "10th Meeting of the EMGM European Meningococcal Disease Society, Manchester, UK",

}

Seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso. / Trotter, CL; Mueller, JE; Yaro, S; Njanpop-Lafourcade, BM; Drabo, A; Diagbouga, SP; Idohou, RS; Bowen, L; Nicolas, P; Findlow, H; Borrow, R.

10th Meeting of the EMGM European Meningococcal Disease Society, Manchester, UK. 2009.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

TY - GEN

T1 - Seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso

AU - Trotter, CL

AU - Mueller, JE

AU - Yaro, S

AU - Njanpop-Lafourcade, BM

AU - Drabo, A

AU - Diagbouga, SP

AU - Idohou, RS

AU - Bowen, L

AU - Nicolas, P

AU - Findlow, H

AU - Borrow, R

PY - 2009/6

Y1 - 2009/6

N2 - Aim To describe the age-specific seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso during the meningitis season of 2008 (non-epidemic year). Methods In February and March 2008, a representative sample of residents of urban Bobo-Dioulasso, Burkina Faso aged 0–59 years participated in a meningococcal seroprevalence (N=1008) and carriage (N=500) study. Serum bactericidal antibody (SBA) titres to strain F8238 (A:4:P1.20,9) were determined using standard methods (rabbit complement). Results The geometric mean titres (GMT) and prevalence of titres ≥8 varied substantially with age. In infants, only 4/107 (4%) had SBA titres >4, but 60% of 1-4 year olds had SBA titres ≥8. Both the GMTs and proportion with SBA titres ≥8 increased in each subsequent age group, peaking in 20-24 year olds (GMT = 488μg/ml, 90% with SBA titre ≥8) before declining in older adults. Provisional results indicate that overall meningococcal carriage prevalence was low (30 years [see abstract by Yaro et al.] The classic Goldschneider curves cannot be replicated in this population, with both high SBA titres and high (hyper-)endemic disease incidence being reported in individuals aged 5-29 years. The absence of detectable serogroup A carriage suggests that exposure to other organisms may induce serum bactericidal activity.

AB - Aim To describe the age-specific seroprevalence of serum bactericidal antibodies to Neisseria meningitidis serogroup A in Burkina Faso during the meningitis season of 2008 (non-epidemic year). Methods In February and March 2008, a representative sample of residents of urban Bobo-Dioulasso, Burkina Faso aged 0–59 years participated in a meningococcal seroprevalence (N=1008) and carriage (N=500) study. Serum bactericidal antibody (SBA) titres to strain F8238 (A:4:P1.20,9) were determined using standard methods (rabbit complement). Results The geometric mean titres (GMT) and prevalence of titres ≥8 varied substantially with age. In infants, only 4/107 (4%) had SBA titres >4, but 60% of 1-4 year olds had SBA titres ≥8. Both the GMTs and proportion with SBA titres ≥8 increased in each subsequent age group, peaking in 20-24 year olds (GMT = 488μg/ml, 90% with SBA titre ≥8) before declining in older adults. Provisional results indicate that overall meningococcal carriage prevalence was low (30 years [see abstract by Yaro et al.] The classic Goldschneider curves cannot be replicated in this population, with both high SBA titres and high (hyper-)endemic disease incidence being reported in individuals aged 5-29 years. The absence of detectable serogroup A carriage suggests that exposure to other organisms may induce serum bactericidal activity.

M3 - Conference Contribution (Conference Proceeding)

BT - 10th Meeting of the EMGM European Meningococcal Disease Society, Manchester, UK

ER -