Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types:: a Mendelian randomisation analysis of the HUNT study

Yi-Qian Sun; Ben Brumpton; Carolina Bonilla; Sarah Lewis; Stephen Burgess; Frank Skorpen; Yue Chen; Tom Il Nilsen; Pal Romundstad; Xiao-Mei Mai

doi:10.1183/13993003.00329-2018

Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study

Yi-Qian Sun, Ben Brumpton, Carolina Bonilla, Sarah Lewis, Stephen Burgess, Frank Skorpen, Yue Chen, Tom Il Nilsen, Pal Romundstad, Xiao-Mei Mai

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Abstract

We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types.

We performed a Mendelian randomization (MR) analysis using a prospective cohort study in Norway, including 54580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Hazard ratios (HRs) with 95% confidence intervals (CIs) for incidence of lung cancer and histologic types were estimated in relation to the allele score. Inverse-variance weighted method using summarized data of individual single-nucleotide polymorphisms was applied to calculate the MR estimates.

The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR being 0.99 (95% CI 0.93 to 1.06) per allele score. A 25 nmol/L increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (MR estimate HR 0.96, 95% CI 0.54 to 1.69) or any histologic type.

MR analysis did not suggest causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.

Original language	English
Journal	European Respiratory Journal
Volume	51
Issue number	6
Early online date	7 Jun 2018
DOIs	https://doi.org/10.1183/13993003.00329-2018
Publication status	E-pub ahead of print - 7 Jun 2018

Keywords

histologic types
lung cancer
Mendelian randomization
serum 25-hydroxyvitamin D [25(OH)D]
single-nucleotide polymorphisms
vitamin D

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10.1183/13993003.00329-2018

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@article{8525e05860354adab7917297d30af6a9,

title = "Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types:: a Mendelian randomisation analysis of the HUNT study",

abstract = "We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomization (MR) analysis using a prospective cohort study in Norway, including 54580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Hazard ratios (HRs) with 95% confidence intervals (CIs) for incidence of lung cancer and histologic types were estimated in relation to the allele score. Inverse-variance weighted method using summarized data of individual single-nucleotide polymorphisms was applied to calculate the MR estimates. The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR being 0.99 (95% CI 0.93 to 1.06) per allele score. A 25 nmol/L increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (MR estimate HR 0.96, 95% CI 0.54 to 1.69) or any histologic type. MR analysis did not suggest causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.",

keywords = "histologic types, lung cancer, Mendelian randomization, serum 25-hydroxyvitamin D [25(OH)D], single-nucleotide polymorphisms, vitamin D",

author = "Yi-Qian Sun and Ben Brumpton and Carolina Bonilla and Sarah Lewis and Stephen Burgess and Frank Skorpen and Yue Chen and Nilsen, {Tom Il} and Pal Romundstad and Xiao-Mei Mai",

year = "2018",

month = jun,

day = "7",

doi = "10.1183/13993003.00329-2018",

language = "English",

volume = "51",

journal = "European Respiratory Journal",

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T1 - Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types:

T2 - a Mendelian randomisation analysis of the HUNT study

AU - Sun, Yi-Qian

AU - Brumpton, Ben

AU - Bonilla, Carolina

AU - Lewis, Sarah

AU - Burgess, Stephen

AU - Skorpen, Frank

AU - Chen, Yue

AU - Nilsen, Tom Il

AU - Romundstad, Pal

AU - Mai, Xiao-Mei

PY - 2018/6/7

Y1 - 2018/6/7

N2 - We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomization (MR) analysis using a prospective cohort study in Norway, including 54580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Hazard ratios (HRs) with 95% confidence intervals (CIs) for incidence of lung cancer and histologic types were estimated in relation to the allele score. Inverse-variance weighted method using summarized data of individual single-nucleotide polymorphisms was applied to calculate the MR estimates. The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR being 0.99 (95% CI 0.93 to 1.06) per allele score. A 25 nmol/L increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (MR estimate HR 0.96, 95% CI 0.54 to 1.69) or any histologic type. MR analysis did not suggest causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.

AB - We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomization (MR) analysis using a prospective cohort study in Norway, including 54580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Hazard ratios (HRs) with 95% confidence intervals (CIs) for incidence of lung cancer and histologic types were estimated in relation to the allele score. Inverse-variance weighted method using summarized data of individual single-nucleotide polymorphisms was applied to calculate the MR estimates. The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR being 0.99 (95% CI 0.93 to 1.06) per allele score. A 25 nmol/L increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (MR estimate HR 0.96, 95% CI 0.54 to 1.69) or any histologic type. MR analysis did not suggest causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.

KW - histologic types

KW - lung cancer

KW - Mendelian randomization

KW - serum 25-hydroxyvitamin D [25(OH)D]

KW - single-nucleotide polymorphisms

KW - vitamin D

U2 - 10.1183/13993003.00329-2018

DO - 10.1183/13993003.00329-2018

M3 - Article (Academic Journal)

C2 - 29748306

VL - 51

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 6

ER -