Serum 25-hydroxyvitamin D, vitamin D supplement and asthma control: The HUNT study

Ben M. Brumpton, Arnulf Langhammer, Anne H. Henriksen, Pål R. Romundstad, Yue Chen, Carlos A. Camargo Jr., Xiao-Mei Mai

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)

Abstract

Abstract Few studies have investigated the association between serum 25-hydroxyvitamin D (25[OH]D), vitamin D supplement and asthma control among adults. We aimed to examine whether low levels of serum 25(OH)D or not taking vitamin D supplement were associated with an increased risk of poorly controlled asthma among Norwegian adults with asthma. We used a definition of asthma control adapted from the Global Initiative for Asthma. We first examined cross-sectional associations between serum 25(OH)D (n = 806) or vitamin D supplement (n = 1179) and poorly controlled asthma. Next, among those with well controlled asthma at baseline, we examined prospective associations between serum 25(OH)D (n = 147) or vitamin D supplement (n = 208) and poorly controlled asthma at follow-up, approximately 11 years later. We estimated risk ratios (RR) and 95% confidence intervals (CI) with Poisson regression. The adjusted RR for poorly controlled asthma was 1.00 (95% CI, 0.89–1.13) for adults with serum 25(OH)D < 50 nmol/L in cross-sectional and 1.50 (95% CI, 0.46–4.95) in prospective analyses. The adjusted RR for poorly controlled asthma was 1.17 (95% CI 1.00–1.37) for non-users of vitamin D supplement in cross-sectional and 1.66 (95% CI 0.49–5.67) in prospective analyses. Our study did not show strong evidence that among adults with asthma, having a low serum 25(OH)D or being a non-user of vitamin D supplement was associated with an increased risk of poorly controlled asthma. Some point estimates indicated an increased risk, however our estimates were generally imprecise and further evidence is needed.
Original languageEnglish
JournalRespiratory Medicine
Early online date31 Jan 2018
DOIs
Publication statusE-pub ahead of print - 31 Jan 2018

Keywords

  • Asthma
  • Epidemiology
  • Vitamin-D

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