Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood

Anna-Maija Tolppanen; Adrian E Sayers; William D Fraser; Glyn H Lewis; Stanley Zammit; John McGrath; Debbie A Lawlor

doi:10.1371/journal.pone.0041575

Serum 25-hydroxyvitamin D₃ and D₂ and non-clinical psychotic experiences in childhood

Anna-Maija Tolppanen, Adrian E Sayers, William D Fraser, Glyn H Lewis, Stanley Zammit, John McGrath, Debbie A Lawlor

Research output: Contribution to journal › Article (Academic Journal) › peer-review

22 Citations (Scopus)

177 Downloads (Pure)

Abstract

Objective

Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D₃ and 25(OH)D₂, have similar associations with psychosis-related outcomes.

Methods

We investigated the association between serum 25(OH)D₃ and 25(OH)D₂ concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D₃ and 25(OH)D₂ concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182).

Results

Higher 25(OH)D₃ concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75–0.95)). Higher concentrations of 25(OH)D₂ were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D₂ concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value.

Conclusions Our findings of an inverse association of 25(OH)D₃ with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes

Original language	English
Article number	e41575
Number of pages	8
Journal	PLoS ONE
Volume	7
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0041575
Publication status	Published - 25 Jul 2012

Keywords

25-Hydroxyvitamin D 2
Adolescent
Adult
Calcifediol
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Male
Prospective Studies
Psychotic Disorders

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2 Finished

THE PUBLIC HEALTH IMPORTANCE OF VITAMIN D: DETERMINING CAUSAL EFFECTS OF INTRAUTERINE AND LIFETIME EXPOSURE TO VITAMIN D
Lawlor, D. A.
1/10/08 → 1/12/13
Project: Research
CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G.
1/09/07 → 1/09/13
Project: Research

Cite this

@article{bfe727b1ea8f4c7da37ce091b8b9ce96,

title = "Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood",

abstract = "Objective Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D3 and 25(OH)D2, have similar associations with psychosis-related outcomes. Methods We investigated the association between serum 25(OH)D3 and 25(OH)D2 concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D3 and 25(OH)D2 concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182). Results Higher 25(OH)D3 concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75–0.95)). Higher concentrations of 25(OH)D2 were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D2 concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value. Conclusions Our findings of an inverse association of 25(OH)D3 with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes",

keywords = "25-Hydroxyvitamin D 2, Adolescent, Adult, Calcifediol, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Psychotic Disorders",

author = "Anna-Maija Tolppanen and Sayers, {Adrian E} and Fraser, {William D} and Lewis, {Glyn H} and Stanley Zammit and John McGrath and Lawlor, {Debbie A}",

year = "2012",

month = jul,

day = "25",

doi = "10.1371/journal.pone.0041575",

language = "English",

volume = "7",

journal = "PLoS ONE",

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T1 - Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood

AU - Tolppanen, Anna-Maija

AU - Sayers, Adrian E

AU - Fraser, William D

AU - Lewis, Glyn H

AU - Zammit, Stanley

AU - McGrath, John

AU - Lawlor, Debbie A

PY - 2012/7/25

Y1 - 2012/7/25

N2 - Objective Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D3 and 25(OH)D2, have similar associations with psychosis-related outcomes. Methods We investigated the association between serum 25(OH)D3 and 25(OH)D2 concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D3 and 25(OH)D2 concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182). Results Higher 25(OH)D3 concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75–0.95)). Higher concentrations of 25(OH)D2 were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D2 concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value. Conclusions Our findings of an inverse association of 25(OH)D3 with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes

AB - Objective Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D3 and 25(OH)D2, have similar associations with psychosis-related outcomes. Methods We investigated the association between serum 25(OH)D3 and 25(OH)D2 concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D3 and 25(OH)D2 concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182). Results Higher 25(OH)D3 concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75–0.95)). Higher concentrations of 25(OH)D2 were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D2 concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value. Conclusions Our findings of an inverse association of 25(OH)D3 with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes

KW - 25-Hydroxyvitamin D 2

KW - Adolescent

KW - Adult

KW - Calcifediol

KW - Child

KW - Child, Preschool

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Prospective Studies

KW - Psychotic Disorders

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DO - 10.1371/journal.pone.0041575

M3 - Article (Academic Journal)

C2 - 22848531

VL - 7

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

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M1 - e41575

ER -