Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.

S. Kluzek, A.C. Bay-Jensen, A. Judge, M.A. Karsdal, M. Shorthose, T. Spector, D. Hart, J.L. Newton, N.K. Arden

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up.The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33-2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared.This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI.
Original languageEnglish
Pages (from-to)557-564
Number of pages8
JournalBiomarkers
Volume20
Issue number8
DOIs
Publication statusPublished - Jan 2015

Bibliographical note

M1 - Print-Electronic

Fingerprint

Dive into the research topics of 'Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.'. Together they form a unique fingerprint.

Cite this