Serum cobalamin concentrations in cats with gastrointestinal signs: correlation with histopathological findings and duration of clinical signs

Christina L. Maunder*, Michael J. Day, Angie Hibbert, Joerg M. Steiner, Jan S. Suchodolski, Edward J. Hall

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)


The aims of this study were to investigate the prevalence of hypocobalaminaemia in UK cats presented for referral investigation of gastrointestinal signs and to ascertain whether the duration of clinical signs or severity of disease (based on WSAVA Gastrointestinal Standardization histopathological grading) related to cobalamin concentration. The study population comprised 39 cats, of which 11 (28.2%) had hypocobalaminaemia. Eight of these cats were diagnosed with a single cause of gastrointestinal signs: intestinal inflammation (five); alimentary lymphoma (two); and cholangitis (one). Two or more concurrent diseases were diagnosed in the three remaining cases. Alimentary lymphoma and the most severe grade of histological intestinal inflammation were associated most commonly with concurrent hypocobalaminaemia, but there was no statistically significant correlation between serum cobalamin concentrations and histopathological score or duration of clinical signs.

Original languageEnglish
Pages (from-to)686-693
Number of pages8
JournalJournal of Feline Medicine and Surgery
Issue number10
Publication statusPublished - Oct 2012


  • Animals
  • Biological Markers
  • Cat Diseases
  • Cats
  • Gastrointestinal Diseases
  • Great Britain
  • Prevalence
  • Vitamin B 12
  • Vitamin B 12 Deficiency

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