Serum haptoglobin concentrations in dogs with liver disease

K. Crawford*, S. M. Warman, A. I. Marques, D. A. Yool, P. D. Eckersall, E. McCulloch, K. Lynn, R. J. Mellanby, Adam Gow

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

Dogs with liver disease have been shown to have increased serum C-reactive protein (CRP) concentrations. However, it is unclear whether dogs with liver disease also have increased serum haptoglobin concentrations. The aim of the study was to measure serum haptoglobin concentrations in healthy dogs, hospitalised dogs and dogs with liver diseases. Haptoglobin concentrations were measured in 30 healthy dogs, 47 hospitalised dogs with non- hepatic illness, 46 dogs with congenital portosystemic shunt (cPSS) and 11 dogs with primary hepatopathy. Haptoglobin concentrations were not significantly different between cPSS dogs with and without hepatic encephalopathy (HE), thus all cPSS dogs were considered as one group. Haptoglobin concentrations were significantly different between the remaining groups (P

Original languageEnglish
Pages (from-to)579-+
Number of pages4
JournalVeterinary Record
Volume173
Issue number23
DOIs
Publication statusPublished - 14 Dec 2013

Keywords

  • C-REACTIVE PROTEIN
  • ACUTE-PHASE RESPONSE
  • BOVINE HEPATOCYTES
  • SECRETION
  • GLYCOPROTEIN
  • EXPRESSION
  • INTERLEUKIN-6
  • INFLAMMATION
  • CYTOKINES
  • FIBROSIS

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