Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma

Samantha S Taylor, Steve Dodkin, Kostas Papasouliotis, Helen Evans, Peter A Graham, Zoe Belshaw, Sara Westberg, Henrik P von Euler

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

The thymidine kinases are enzymes that convert deoxythymidine to deoxythymidine monophosphate and have a function in DNA synthesis. Rapidly proliferating cells will have higher levels of thymidine kinase. Serum thymidine kinase activity (sTK) is a useful tumour marker in humans and dogs, with utility as a prognostic indicator in lymphoma. In the current study serum samples were collected from 49 clinically healthy cats, 33 with lymphoma, 55 with inflammatory disease and 34 with non-haematopoietic neoplasia (NHPN). sTK was measured using a radioenzyme assay and a reference interval (1.96 × SD) was established from the clinically healthy cats (
Original languageEnglish
Pages (from-to)142-7
Number of pages6
JournalJournal of Feline Medicine and Surgery
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Animals
  • Cat Diseases
  • Cats
  • Female
  • Lymphoma
  • Male
  • Sensitivity and Specificity
  • Thymidine Kinase
  • Tumor Markers, Biological

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