Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma

Samantha S Taylor; Steve Dodkin; Kostas Papasouliotis; Helen Evans; Peter A Graham; Zoe Belshaw; Sara Westberg; Henrik P von Euler

doi:10.1177/1098612X12463928

Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma

Samantha S Taylor, Steve Dodkin, Kostas Papasouliotis, Helen Evans, Peter A Graham, Zoe Belshaw, Sara Westberg, Henrik P von Euler

Research output: Contribution to journal › Article (Academic Journal) › peer-review

13 Citations (Scopus)

Abstract

The thymidine kinases are enzymes that convert deoxythymidine to deoxythymidine monophosphate and have a function in DNA synthesis. Rapidly proliferating cells will have higher levels of thymidine kinase. Serum thymidine kinase activity (sTK) is a useful tumour marker in humans and dogs, with utility as a prognostic indicator in lymphoma. In the current study serum samples were collected from 49 clinically healthy cats, 33 with lymphoma, 55 with inflammatory disease and 34 with non-haematopoietic neoplasia (NHPN). sTK was measured using a radioenzyme assay and a reference interval (1.96 × SD) was established from the clinically healthy cats (

Original language	English
Pages (from-to)	142-7
Number of pages	6
Journal	Journal of Feline Medicine and Surgery
Volume	15
Issue number	2
DOIs	https://doi.org/10.1177/1098612X12463928
Publication status	Published - Feb 2013

Keywords

Animals
Cat Diseases
Cats
Female
Lymphoma
Male
Sensitivity and Specificity
Thymidine Kinase
Tumor Markers, Biological

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title = "Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma",

abstract = "The thymidine kinases are enzymes that convert deoxythymidine to deoxythymidine monophosphate and have a function in DNA synthesis. Rapidly proliferating cells will have higher levels of thymidine kinase. Serum thymidine kinase activity (sTK) is a useful tumour marker in humans and dogs, with utility as a prognostic indicator in lymphoma. In the current study serum samples were collected from 49 clinically healthy cats, 33 with lymphoma, 55 with inflammatory disease and 34 with non-haematopoietic neoplasia (NHPN). sTK was measured using a radioenzyme assay and a reference interval (1.96 × SD) was established from the clinically healthy cats (",

keywords = "Animals, Cat Diseases, Cats, Female, Lymphoma, Male, Sensitivity and Specificity, Thymidine Kinase, Tumor Markers, Biological",

author = "Taylor, \{Samantha S\} and Steve Dodkin and Kostas Papasouliotis and Helen Evans and Graham, \{Peter A\} and Zoe Belshaw and Sara Westberg and \{von Euler\}, \{Henrik P\}",

year = "2013",

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doi = "10.1177/1098612X12463928",

language = "English",

volume = "15",

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journal = "Journal of Feline Medicine and Surgery",

issn = "1098-612X",

publisher = "SAGE Publications Inc.",

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TY - JOUR

T1 - Serum thymidine kinase activity in clinically healthy and diseased cats

T2 - a potential biomarker for lymphoma

AU - Taylor, Samantha S

AU - Dodkin, Steve

AU - Papasouliotis, Kostas

AU - Evans, Helen

AU - Graham, Peter A

AU - Belshaw, Zoe

AU - Westberg, Sara

AU - von Euler, Henrik P

PY - 2013/2

Y1 - 2013/2

N2 - The thymidine kinases are enzymes that convert deoxythymidine to deoxythymidine monophosphate and have a function in DNA synthesis. Rapidly proliferating cells will have higher levels of thymidine kinase. Serum thymidine kinase activity (sTK) is a useful tumour marker in humans and dogs, with utility as a prognostic indicator in lymphoma. In the current study serum samples were collected from 49 clinically healthy cats, 33 with lymphoma, 55 with inflammatory disease and 34 with non-haematopoietic neoplasia (NHPN). sTK was measured using a radioenzyme assay and a reference interval (1.96 × SD) was established from the clinically healthy cats (

AB - The thymidine kinases are enzymes that convert deoxythymidine to deoxythymidine monophosphate and have a function in DNA synthesis. Rapidly proliferating cells will have higher levels of thymidine kinase. Serum thymidine kinase activity (sTK) is a useful tumour marker in humans and dogs, with utility as a prognostic indicator in lymphoma. In the current study serum samples were collected from 49 clinically healthy cats, 33 with lymphoma, 55 with inflammatory disease and 34 with non-haematopoietic neoplasia (NHPN). sTK was measured using a radioenzyme assay and a reference interval (1.96 × SD) was established from the clinically healthy cats (

KW - Animals

KW - Cat Diseases

KW - Cats

KW - Female

KW - Lymphoma

KW - Male

KW - Sensitivity and Specificity

KW - Thymidine Kinase

KW - Tumor Markers, Biological

U2 - 10.1177/1098612X12463928

DO - 10.1177/1098612X12463928

M3 - Article (Academic Journal)

C2 - 23076596

SN - 1098-612X

VL - 15

SP - 142

EP - 147

JO - Journal of Feline Medicine and Surgery

JF - Journal of Feline Medicine and Surgery

IS - 2

ER -

Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma

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