TY - GEN
T1 - Severity of Omicron (B.1.1.529) and Delta (B.1.1.617.2) SARS-CoV-2 infection among hospitalised adults: a prospective cohort study
AU - Hyams, Catherine
AU - Challen, Robert J
AU - Marlow, Robin D
AU - Nguyen, Jennifer
AU - Begier, Elizabeth
AU - Southern, Jo
AU - King, Jade N
AU - Morley, Anna
AU - Kinney, Jane D
AU - Clout, Maddie J
AU - Oliver, Jennifer L
AU - Ellsbury, Gillian
AU - Maskell, Nick A
AU - Jodar, Luis
AU - Gessner, Bradford
AU - McLaughlin, John
AU - Danon, Leon
AU - Finn, Adam H R
PY - 2022/7/7
Y1 - 2022/7/7
N2 - Limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 variant infections, and to what extent patient-factors, including vaccination and pre-existing disease, affect variant-dependent disease severity. This prospective cohort study of all adults (≥18 years of age) hospitalised at acute care hospitals in Bristol, UK assessed disease severity using 3 different measures: FiO2 >28%, World Health Organization (WHO) outcome score >5, and hospital length of stay (LOS) >3 days following admission for Omicron or Delta variant infection. Independent of other variables, including vaccination, Omicron variant infection was associated with a statistically lower severity compared to Delta; risk reductions were 58%, 67%, and 16% for FiO2, WHO score, and LOS, respectively. Younger age and vaccination with two or three doses were also independently associated with lower COVID-19 severity. Despite lower severity relative to Delta, Omicron infection still resulted in substantial patient and public health burden following admission.
AB - Limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 variant infections, and to what extent patient-factors, including vaccination and pre-existing disease, affect variant-dependent disease severity. This prospective cohort study of all adults (≥18 years of age) hospitalised at acute care hospitals in Bristol, UK assessed disease severity using 3 different measures: FiO2 >28%, World Health Organization (WHO) outcome score >5, and hospital length of stay (LOS) >3 days following admission for Omicron or Delta variant infection. Independent of other variables, including vaccination, Omicron variant infection was associated with a statistically lower severity compared to Delta; risk reductions were 58%, 67%, and 16% for FiO2, WHO score, and LOS, respectively. Younger age and vaccination with two or three doses were also independently associated with lower COVID-19 severity. Despite lower severity relative to Delta, Omicron infection still resulted in substantial patient and public health burden following admission.
UR - http://dx.doi.org/10.21203/rs.3.rs-1808133/v1
U2 - 10.21203/rs.3.rs-1808133/v1
DO - 10.21203/rs.3.rs-1808133/v1
M3 - Other contribution
ER -
