Projects per year
Abstract
Limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 variant infections, and to what extent patient-factors, including vaccination and pre-existing disease, affect variant-dependent disease severity. This prospective cohort study of all adults (≥18 years of age) hospitalised at acute care hospitals in Bristol, UK assessed disease severity using 3 different measures: FiO2 >28%, World Health Organization (WHO) outcome score >5, and hospital length of stay (LOS) >3 days following admission for Omicron or Delta variant infection. Independent of other variables, including vaccination, Omicron variant infection was associated with a statistically lower severity compared to Delta; risk reductions were 58%, 67%, and 16% for FiO2, WHO score, and LOS, respectively. Younger age and vaccination with two or three doses were also independently associated with lower COVID-19 severity. Despite lower severity relative to Delta, Omicron infection still resulted in substantial patient and public health burden following admission.
Original language | Undefined/Unknown |
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DOIs | |
Publication status | Published - 7 Jul 2022 |
Research Groups and Themes
- Covid19
- Academic Respiratory Unit
Projects
- 1 Finished
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The AvonCAP Study
Hyams, C. (Principal Investigator) & Finn, A. H. R. (Principal Investigator)
1/10/20 → 1/10/24
Project: Research