Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study

DA Lawlor, S Ebrahim, P Whincup, JAC Sterne, C Papacosta, G Wannamethee, S Dhanjil, M Griffin, AN Nicolaides, G Davey Smith

Research output: Contribution to journalArticle (Academic Journal)peer-review

22 Citations (Scopus)

Abstract

Objective: To determine the role of central adiposity in explaining sex differences in carotid intima media thickness (IMT). Design: Cross sectional survey. Setting: Two British towns. Participants: 800 men and women aged 56–75 years. Main outcome measures: Carotid IMT. Results: There was a continuous linear association between waist-hip ratio and IMT in both men and women. The magnitude of the association between waist to hip ratio and IMT was identical in both sexes. In age adjusted analyses IMT was 14% greater in men compared with women (age adjusted male to female ratio of geometric means 1.14; 95% confidence interval 1.07 to 1.21) with adjustment for waist to hip ratio this attenuated to no difference (1.00; 0.92 to 1.09). Adjustment for body mass index and for lifestyle risk factors had very little effect on the sex difference in mean intima media thickness. Conclusions: Sex differences in body fat distribution may explain sex differences in arterial atherosclerosis.
Translated title of the contributionSex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study
Original languageEnglish
Pages (from-to)700 - 704
Number of pages4
JournalJournal of Epidemiology and Community Health
Volume58(8)
DOIs
Publication statusPublished - Aug 2004

Bibliographical note

Other identifier: PMID: 15252075

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