Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study

DA Lawlor; S Ebrahim; P Whincup; JAC Sterne; C Papacosta; G Wannamethee; S Dhanjil; M Griffin; AN Nicolaides; G Davey Smith

doi:10.1136/jech.2003.014001

Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study

DA Lawlor, S Ebrahim, P Whincup, JAC Sterne, C Papacosta, G Wannamethee, S Dhanjil, M Griffin, AN Nicolaides, G Davey Smith

Research output: Contribution to journal › Article (Academic Journal) › peer-review

25 Citations (Scopus)

Abstract

Objective: To determine the role of central adiposity in explaining sex differences in carotid intima media thickness (IMT). Design: Cross sectional survey. Setting: Two British towns. Participants: 800 men and women aged 56–75 years. Main outcome measures: Carotid IMT. Results: There was a continuous linear association between waist-hip ratio and IMT in both men and women. The magnitude of the association between waist to hip ratio and IMT was identical in both sexes. In age adjusted analyses IMT was 14% greater in men compared with women (age adjusted male to female ratio of geometric means 1.14; 95% confidence interval 1.07 to 1.21) with adjustment for waist to hip ratio this attenuated to no difference (1.00; 0.92 to 1.09). Adjustment for body mass index and for lifestyle risk factors had very little effect on the sex difference in mean intima media thickness. Conclusions: Sex differences in body fat distribution may explain sex differences in arterial atherosclerosis.

Translated title of the contribution	Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study
Original language	English
Pages (from-to)	700 - 704
Number of pages	4
Journal	Journal of Epidemiology and Community Health
Volume	58(8)
DOIs	https://doi.org/10.1136/jech.2003.014001
Publication status	Published - Aug 2004

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Other identifier: PMID: 15252075

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http://www.ncbi.nlm.nih.gov/pubmed/15252075?dopt=Abstract

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Lawlor, DA., Ebrahim, S., Whincup, P., Sterne, JAC., Papacosta, C., Wannamethee, G., Dhanjil, S., Griffin, M., Nicolaides, AN., & Davey Smith, G. (2004). Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study. Journal of Epidemiology and Community Health, 58(8), 700 - 704. https://doi.org/10.1136/jech.2003.014001

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title = "Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study",

abstract = "Objective: To determine the role of central adiposity in explaining sex differences in carotid intima media thickness (IMT). Design: Cross sectional survey. Setting: Two British towns. Participants: 800 men and women aged 56–75 years. Main outcome measures: Carotid IMT. Results: There was a continuous linear association between waist-hip ratio and IMT in both men and women. The magnitude of the association between waist to hip ratio and IMT was identical in both sexes. In age adjusted analyses IMT was 14% greater in men compared with women (age adjusted male to female ratio of geometric means 1.14; 95% confidence interval 1.07 to 1.21) with adjustment for waist to hip ratio this attenuated to no difference (1.00; 0.92 to 1.09). Adjustment for body mass index and for lifestyle risk factors had very little effect on the sex difference in mean intima media thickness. Conclusions: Sex differences in body fat distribution may explain sex differences in arterial atherosclerosis.",

author = "DA Lawlor and S Ebrahim and P Whincup and JAC Sterne and C Papacosta and G Wannamethee and S Dhanjil and M Griffin and AN Nicolaides and {Davey Smith}, G",

note = "Other identifier: PMID: 15252075 ",

year = "2004",

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doi = "10.1136/jech.2003.014001",

language = "English",

volume = "58(8)",

pages = "700 -- 704",

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Lawlor, DA, Ebrahim, S, Whincup, P, Sterne, JAC, Papacosta, C, Wannamethee, G, Dhanjil, S, Griffin, M, Nicolaides, AN & Davey Smith, G 2004, 'Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study', Journal of Epidemiology and Community Health, vol. 58(8), pp. 700 - 704. https://doi.org/10.1136/jech.2003.014001

TY - JOUR

T1 - Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study

AU - Lawlor, DA

AU - Ebrahim, S

AU - Whincup, P

AU - Sterne, JAC

AU - Papacosta, C

AU - Wannamethee, G

AU - Dhanjil, S

AU - Griffin, M

AU - Nicolaides, AN

AU - Davey Smith, G

N1 - Other identifier: PMID: 15252075

PY - 2004/8

Y1 - 2004/8

N2 - Objective: To determine the role of central adiposity in explaining sex differences in carotid intima media thickness (IMT). Design: Cross sectional survey. Setting: Two British towns. Participants: 800 men and women aged 56–75 years. Main outcome measures: Carotid IMT. Results: There was a continuous linear association between waist-hip ratio and IMT in both men and women. The magnitude of the association between waist to hip ratio and IMT was identical in both sexes. In age adjusted analyses IMT was 14% greater in men compared with women (age adjusted male to female ratio of geometric means 1.14; 95% confidence interval 1.07 to 1.21) with adjustment for waist to hip ratio this attenuated to no difference (1.00; 0.92 to 1.09). Adjustment for body mass index and for lifestyle risk factors had very little effect on the sex difference in mean intima media thickness. Conclusions: Sex differences in body fat distribution may explain sex differences in arterial atherosclerosis.

AB - Objective: To determine the role of central adiposity in explaining sex differences in carotid intima media thickness (IMT). Design: Cross sectional survey. Setting: Two British towns. Participants: 800 men and women aged 56–75 years. Main outcome measures: Carotid IMT. Results: There was a continuous linear association between waist-hip ratio and IMT in both men and women. The magnitude of the association between waist to hip ratio and IMT was identical in both sexes. In age adjusted analyses IMT was 14% greater in men compared with women (age adjusted male to female ratio of geometric means 1.14; 95% confidence interval 1.07 to 1.21) with adjustment for waist to hip ratio this attenuated to no difference (1.00; 0.92 to 1.09). Adjustment for body mass index and for lifestyle risk factors had very little effect on the sex difference in mean intima media thickness. Conclusions: Sex differences in body fat distribution may explain sex differences in arterial atherosclerosis.

U2 - 10.1136/jech.2003.014001

DO - 10.1136/jech.2003.014001

M3 - Article (Academic Journal)

SN - 1470-2738

VL - 58(8)

SP - 700

EP - 704

JO - Journal of Epidemiology and Community Health

JF - Journal of Epidemiology and Community Health

ER -

Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British Regional Heart Study

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