Sex differences in the association betwen birth weight and total cholesterol. A meta-analysis

DA Lawlor, CG Owen, AA Davies, PH Whincup, S Ebrahim, DG Cook, G Davey Smith

Research output: Contribution to journalArticle (Academic Journal)peer-review

44 Citations (Scopus)

Abstract

Purpose Determine whether a sex difference exists in the association between birth weight and total cholesterol later in life. Methods Meta-analysis of within-study differences in regression coefficients of cholesterol on birth weight. Results A total of 34 regression coefficients from 30 studies were included in the analyses; these provided data on 33,650 males and 23,129 females. There was evidence that the inverse association between birth weight and total cholesterol was stronger in males compared to females. The pooled within-study difference in age-adjusted regression coefficients was −0.03 mmol/l (−0.06, −0.01), p = 0.02 and the pooled within-study difference in age and body mass index adjusted regression coefficients was −0.04 mmol/l (−0.07, −0.02), p = 0.002. There was no evidence of heterogeneity in these meta-analyses (both p values > 0.6). Conclusions These results provide some evidence for a sex difference in the birth weight – total cholesterol association. This is consistent with studies of fetal growth which suggest that birth size reflects different biological processes for females and males. However, other very large studies are required to confirm this finding.
Translated title of the contributionSex differences in the association betwen birth weight and total cholesterol. A meta-analysis
Original languageEnglish
Pages (from-to)19 - 25
Number of pages7
JournalAnnals of Epidemiology
Volume16
DOIs
Publication statusPublished - Apr 2006

Bibliographical note

Publisher: Elsevier Science Publishing Company for The American College of Epidemiology

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