Sex-Differences in the Metabolic Health of Offspring of Parents with Diabetes: A Record-Linkage Study

Generation Scotland

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Maternal diabetes in pregnancy affects offspring health. The impact of parental diabetes on offspring health is unclear. We investigated the impact of parental diabetes on the metabolic-health of adult-offspring who did not themselves have diabetes. Data from the Generation Scotland: Scottish Family Health Study, a population-based family cohort, were record-linked to subjects' own diabetes medical records. From F0-parents, we identified F1-offspring of: mothers with diabetes (OMD, n = 409), fathers with diabetes (OFD, n = 468), no parent with diabetes (ONoPD, n = 2489). Metabolic syndrome, body, biochemical measurements and blood-pressures were compared between F1-offspring groups by sex. A higher proportion of female OMD had metabolic syndrome than female OFD or ONoPD (P<0.0001). In female offspring, predictors of metabolic syndrome were: having a mother with diabetes (OR = 1.78, CI 1.03-3.07, [reference ONoPD]), body mass index (BMI, OR = 1.21, CI 1.13-1.30) and age (OR = 1.03, CI 1.01-1.06). In male offspring, predictors of metabolic syndrome were: BMI (OR = 1.18, CI 1.09-1.29) and percent body-fat (OR = 1.12, CI 1.05-1.19). In both sexes, OMD had higher blood-pressures than OFD (P<0.0001). In females, OMD had higher glucose (P<0.0001) and percent body-fat (P<0.0001) compared with OFD or ONoPD. OMD and OFD both had increased waist-measurements (P<0.0001), BMI (P<0.0001) and percent body-fat (P<0.0001) compared with ONoPD. Female OMD and OFD had lower HDL-cholesterol levels (P<0.0001) than female ONoPD. Parental diabetes is associated with higher offspring-BMI and body-fat. In female offspring, maternal diabetes increased the odds of metabolic syndrome, even after adjusting for BMI. Further investigations are required to determine the mechanisms involved.

Original languageEnglish
Pages (from-to)e0134883
JournalPLoS ONE
Volume10
Issue number8
DOIs
Publication statusPublished - 2015

Keywords

  • Adolescent
  • Adult
  • Adult Children/statistics & numerical data
  • Blood Pressure
  • Body Mass Index
  • Cohort Studies
  • Comorbidity
  • Diabetes Mellitus
  • Diabetes, Gestational
  • Fathers
  • Female
  • Grandparents
  • Health
  • Humans
  • Male
  • Metabolic Syndrome/epidemiology
  • Mothers
  • Pregnancy
  • Sex Characteristics
  • Smoking
  • Young Adult

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