Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Joshua C Randall; Thomas W Winkler; Zoltán Kutalik; Sonja I Berndt; Anne U Jackson; Keri L Monda; Tuomas O Kilpeläinen; Tõnu Esko; Reedik Mägi; Shengxu Li; Tsegaselassie Workalemahu; Mary F Feitosa; Damien C Croteau-Chonka; Felix R Day; Tove Fall; Teresa Ferreira; Stefan Gustafsson; Adam E Locke; Iain Mathieson; Andre Scherag; Sailaja Vedantam; Andrew R Wood; Liming Liang; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Emmanouil T Dermitzakis; Antigone S Dimas; Fredrik Karpe; Josine L Min; George Nicholson; Deborah J Clegg; Thomas Person; Jon P Krohn; Sabrina Bauer; Christa Buechler; Kristina Eisinger; Amélie Bonnefond; Philippe Froguel; Jouke-Jan Hottenga; Inga Prokopenko; Lindsay L Waite; Tamara B Harris; Albert Vernon Smith; Alan R Shuldiner; Wendy L McArdle; Mark J Caulfield; Lyle J Palmer; Sarah E Medland; Dmitry Shungin; Mika Kivimaki; DIAGRAM Consortium

doi:10.1371/journal.pgen.1003500

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Joshua C Randall
, Thomas W Winkler
, Zoltán Kutalik
, Sonja I Berndt
, Anne U Jackson
, Keri L Monda
, Tuomas O Kilpeläinen
, Tõnu Esko
, Reedik Mägi
, Shengxu Li
, Tsegaselassie Workalemahu
, Mary F Feitosa
, Damien C Croteau-Chonka
, Felix R Day
, Tove Fall
, Teresa Ferreira
, Stefan Gustafsson
, Adam E Locke
, Iain Mathieson
, Andre Scherag

Sailaja Vedantam, Andrew R Wood, Liming Liang, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Emmanouil T Dermitzakis, Antigone S Dimas, Fredrik Karpe, Josine L Min, George Nicholson, Deborah J Clegg, Thomas Person, Jon P Krohn, Sabrina Bauer, Christa Buechler, Kristina Eisinger, Amélie Bonnefond, Philippe Froguel, Jouke-Jan Hottenga, Inga Prokopenko, Lindsay L Waite, Tamara B Harris, Albert Vernon Smith, Alan R Shuldiner, Wendy L McArdle, Mark J Caulfield, Lyle J Palmer, Sarah E Medland, Dmitry Shungin, Mika Kivimaki, DIAGRAM Consortium

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

347 Citations (Scopus)

Abstract

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

Original language	English
Pages (from-to)	e1003500
Journal	PLOS Genetics
Volume	9
Issue number	6
DOIs	https://doi.org/10.1371/journal.pgen.1003500
Publication status	Published - Jun 2013

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Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpeläinen, T. O., Esko, T., Mägi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., Mathieson, I., ... DIAGRAM Consortium (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLOS Genetics, 9(6), e1003500. https://doi.org/10.1371/journal.pgen.1003500

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title = "Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits",

abstract = "Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR",

author = "Randall, \{Joshua C\} and Winkler, \{Thomas W\} and Zolt{\'a}n Kutalik and Berndt, \{Sonja I\} and Jackson, \{Anne U\} and Monda, \{Keri L\} and Kilpel{\"a}inen, \{Tuomas O\} and T{\~o}nu Esko and Reedik M{\"a}gi and Shengxu Li and Tsegaselassie Workalemahu and Feitosa, \{Mary F\} and Croteau-Chonka, \{Damien C\} and Day, \{Felix R\} and Tove Fall and Teresa Ferreira and Stefan Gustafsson and Locke, \{Adam E\} and Iain Mathieson and Andre Scherag and Sailaja Vedantam and Wood, \{Andrew R\} and Liming Liang and Valgerdur Steinthorsdottir and Gudmar Thorleifsson and Dermitzakis, \{Emmanouil T\} and Dimas, \{Antigone S\} and Fredrik Karpe and Min, \{Josine L\} and George Nicholson and Clegg, \{Deborah J\} and Thomas Person and Krohn, \{Jon P\} and Sabrina Bauer and Christa Buechler and Kristina Eisinger and Am{\'e}lie Bonnefond and Philippe Froguel and Jouke-Jan Hottenga and Inga Prokopenko and Waite, \{Lindsay L\} and Harris, \{Tamara B\} and Smith, \{Albert Vernon\} and Shuldiner, \{Alan R\} and McArdle, \{Wendy L\} and Caulfield, \{Mark J\} and Palmer, \{Lyle J\} and Medland, \{Sarah E\} and Dmitry Shungin and Mika Kivimaki and \{DIAGRAM Consortium\}",

year = "2013",

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doi = "10.1371/journal.pgen.1003500",

language = "English",

volume = "9",

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Randall, JC, Winkler, TW, Kutalik, Z, Berndt, SI, Jackson, AU, Monda, KL, Kilpeläinen, TO, Esko, T, Mägi, R, Li, S, Workalemahu, T, Feitosa, MF, Croteau-Chonka, DC, Day, FR, Fall, T, Ferreira, T, Gustafsson, S, Locke, AE, Mathieson, I, Scherag, A, Vedantam, S, Wood, AR, Liang, L, Steinthorsdottir, V, Thorleifsson, G, Dermitzakis, ET, Dimas, AS, Karpe, F, Min, JL, Nicholson, G, Clegg, DJ, Person, T, Krohn, JP, Bauer, S, Buechler, C, Eisinger, K, Bonnefond, A, Froguel, P, Hottenga, J-J, Prokopenko, I, Waite, LL, Harris, TB, Smith, AV, Shuldiner, AR, McArdle, WL, Caulfield, MJ, Palmer, LJ, Medland, SE, Shungin, D, Kivimaki, M & DIAGRAM Consortium 2013, 'Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits', PLOS Genetics, vol. 9, no. 6, pp. e1003500. https://doi.org/10.1371/journal.pgen.1003500

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T1 - Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

AU - Randall, Joshua C

AU - Winkler, Thomas W

AU - Kutalik, Zoltán

AU - Berndt, Sonja I

AU - Jackson, Anne U

AU - Monda, Keri L

AU - Kilpeläinen, Tuomas O

AU - Esko, Tõnu

AU - Mägi, Reedik

AU - Li, Shengxu

AU - Workalemahu, Tsegaselassie

AU - Feitosa, Mary F

AU - Croteau-Chonka, Damien C

AU - Day, Felix R

AU - Fall, Tove

AU - Ferreira, Teresa

AU - Gustafsson, Stefan

AU - Locke, Adam E

AU - Mathieson, Iain

AU - Scherag, Andre

AU - Vedantam, Sailaja

AU - Wood, Andrew R

AU - Liang, Liming

AU - Steinthorsdottir, Valgerdur

AU - Thorleifsson, Gudmar

AU - Dermitzakis, Emmanouil T

AU - Dimas, Antigone S

AU - Karpe, Fredrik

AU - Min, Josine L

AU - Nicholson, George

AU - Clegg, Deborah J

AU - Person, Thomas

AU - Krohn, Jon P

AU - Bauer, Sabrina

AU - Buechler, Christa

AU - Eisinger, Kristina

AU - Bonnefond, Amélie

AU - Froguel, Philippe

AU - Hottenga, Jouke-Jan

AU - Prokopenko, Inga

AU - Waite, Lindsay L

AU - Harris, Tamara B

AU - Smith, Albert Vernon

AU - Shuldiner, Alan R

AU - McArdle, Wendy L

AU - Caulfield, Mark J

AU - Palmer, Lyle J

AU - Medland, Sarah E

AU - Shungin, Dmitry

AU - Kivimaki, Mika

AU - DIAGRAM Consortium

PY - 2013/6

Y1 - 2013/6

N2 - Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

AB - Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

U2 - 10.1371/journal.pgen.1003500

DO - 10.1371/journal.pgen.1003500

M3 - Article (Academic Journal)

C2 - 23754948

SN - 1553-7404

VL - 9

SP - e1003500

JO - PLOS Genetics

JF - PLOS Genetics

IS - 6

ER -

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

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