Shank mutant mice as an animal model of autism

Juyoun Yoo, Joseph Bakes, Clarrisa Bradley, Graham L Collingridge, Bong-Kiun Kaang

Research output: Contribution to journalArticle (Academic Journal)peer-review

49 Citations (Scopus)


In this review, we focus on the role of the Shank family of proteins in autism. In recent years, autism research has been flourishing. With genetic, molecular, imaging and electrophysiological studies being supported by behavioural studies using animal models, there is real hope that we may soon understand the fundamental pathology of autism. There is also genuine potential to develop a molecular-level pharmacological treatment that may be able to deal with the most severe symptoms of autism, and clinical trials are already underway. The Shank family of proteins has been strongly implicated as a contributing factor in autism in certain individuals and sits at the core of the alleged autistic pathway. Here, we analyse studies that relate Shank to autism and discuss what light this sheds on the possible causes of autism.
Original languageEnglish
Article number20130143
Number of pages13
JournalProceedings of the Royal Society B: Biological Sciences
Issue number1633
Early online date2 Dec 2013
Publication statusPublished - 5 Jan 2014


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