SHARPINing integrin inhibition

MD Bass

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)


The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins.
Translated title of the contributionSHARPINing integrin inhibition
Original languageEnglish
Pages (from-to)1292 - 1293
Number of pages2
JournalNature Cell Biology
Publication statusPublished - Nov 2011

Bibliographical note

Title of Publication Reviewed: SHARPIN is an endogenous inhibitor of β1-integrin activation
Author of Publication Reviewed: Rantala, Pouwels, Pellinen, Veltel, Laasola, Mattila, Potter, Duffy, Sundberg, Kallioniemi, Askari, Humphries, Parsons, Salmi & Ivaska


Dive into the research topics of 'SHARPINing integrin inhibition'. Together they form a unique fingerprint.

Cite this