Abstract
The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins.
Translated title of the contribution | SHARPINing integrin inhibition |
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Original language | English |
Pages (from-to) | 1292 - 1293 |
Number of pages | 2 |
Journal | Nature Cell Biology |
Volume | 13 |
DOIs | |
Publication status | Published - Nov 2011 |
Bibliographical note
Title of Publication Reviewed: SHARPIN is an endogenous inhibitor of β1-integrin activationAuthor of Publication Reviewed: Rantala, Pouwels, Pellinen, Veltel, Laasola, Mattila, Potter, Duffy, Sundberg, Kallioniemi, Askari, Humphries, Parsons, Salmi & Ivaska