Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations

Christopher A. Brown, Varinder K. Aggarwal*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)
285 Downloads (Pure)

Abstract

Using iterative lithiation-borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17 % overall yield. The rapid build-up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis. Rapid complexity: Using iterative lithiation-borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17 % overall yield. The rapid build-up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of the synthesis

Original languageEnglish
Pages (from-to)13900-13903
Number of pages4
JournalChemistry - A European Journal
Volume21
Issue number40
DOIs
Publication statusPublished - 1 Sep 2015

Keywords

  • asymmetric synthesis
  • boron
  • iterative homologation
  • mycolactone
  • natural products

Fingerprint Dive into the research topics of 'Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations'. Together they form a unique fingerprint.

Cite this