Projects per year
Abstract
The universal mating hormone 1 of the virulent plant pathogen Phytophthora has been synthesized in 12 steps and 28% overall yield. Key CC bond-forming steps involved the use of two lithiation/borylation reactions to couple together enantioenriched building blocks, one of which also set up the stereochemistry of the tertiary alcohol at C11. Detailed analysis showed that the diastereomeric purity of the target molecule was >91%, the highest obtained to date.
Original language | English |
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Pages (from-to) | 4382-4385 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 53 |
Issue number | 17 |
DOIs | |
Publication status | Published - 22 Apr 2014 |
Keywords
- asymmetric synthesis
- boron
- lithium
- natural products
- total synthesis
- 4 STEREOISOMERS
- BORONIC ESTERS
- ALPHA-1
- BORANES
Fingerprint
Dive into the research topics of 'Short Stereoselective Synthesis of the Phytophthora Universal Mating Hormone alpha 1 Using Lithiation/Borylation Reactions'. Together they form a unique fingerprint.Projects
- 2 Finished
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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Changing the Synthesis Landscape with Boron at the Helm: from Chiral Organometallics to Assembly Line Synthesis
Aggarwal, V. K. (Principal Investigator)
14/05/12 → 13/01/18
Project: Research
Profiles
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Professor Varinder K Aggarwal
- School of Chemistry - Alfred Capper Pass Chair of Chemistry
Person: Academic